Domains within Kluyveromyces lactis NRRL Y-1140 protein MSH3_KLULA (Q6CSR1)

DNA mismatch repair protein MSH3

Alternative representations: 1 /

Protein length1029 aa
Source databaseUniProt
Identifiers MSH3_KLULA, Q6CSR1

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

MSH3_KLULA is shown as MSH3 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for MSH3

Protein MSH3_KLULA is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map03430Mismatch repair
map01524Platinum drug resistance

KEGG orthologous groups

KONameDescription
K08736MSH3DNA mismatch repair protein MSH3
K03555mutSDNA mismatch repair protein MutS

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 284590.Q6CSR1 in eggNOG.

OGTaxonomic classDescription
FQWDVDikarya (subkingdom)DNA mismatch repair protein MSH3
LCOG0249All organisms (root)DNA mismatch repair protein MutS,DNA mismatch repair protein MSH6,DNA mismatch repair protein MSH2
KOG0218Eukaryota (superkingdom)DNA mismatch repair protein MSH3
BNXP9Fungi (kingdom)DNA mismatch repair protein MSH3
9TSBCAscomycota (phylum)DNA mismatch repair protein MSH3
91FNHSaccharomycetales (order)DNA mismatch repair protein MSH3
7GH5YOpisthokonta (clade)DNA mismatch repair protein MSH3
AT89ESaccharomycetaceae (family)DNA mismatch repair protein MSH3

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: