Domains within Rattus norvegicus protein Q6MG86_RAT (Q6MG86)

Advanced glycosylation end product-specific receptor

Alternative representations: 1 /

Protein length402 aa
Source databaseUniProt
Identifiers Q6MG86_RAT, Q6MG86, ENSRNOP00000000508.1, ENSRNOP00000000508
Source gene ENSRNOG00000000439
Alternative splicing Q6MG86_RAT, A0A0G2K218_RAT, M0RAU0_RAT, A0A0G2KAP4_RAT, A0A0G2K653_RAT

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

Q6MG86_RAT is shown as Ager in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Ager

Protein Q6MG86_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04120Ubiquitin mediated proteolysis
map05415Diabetic cardiomyopathy

KEGG orthologous groups

KONameDescription
K06712BTN, CD277butyrophilin
K19722AGER, RAGEreceptor for advanced glycosylation end products

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000000508 in eggNOG.

OGTaxonomic classDescription
LKOG2177All organisms (root)butyrophilin,tripartite motif-containing protein 2/3,deltex [EC:2.3.2.27]
KOG2177Eukaryota (superkingdom)butyrophilin,tripartite motif-containing protein 2/3,deltex [EC:2.3.2.27]
HV2J8Metazoa (kingdom)receptor for advanced glycosylation end products
940T7Chordata (phylum)receptor for advanced glycosylation end products
5QSTGSarcopterygii (superclass)receptor for advanced glycosylation end products
8ZMYNMammalia (class)receptor for advanced glycosylation end products
4RMKVEuarchontoglires (superorder)receptor for advanced glycosylation end products
AI92YRodentia (order)receptor for advanced glycosylation end products
8DAEIMyomorpha (suborder)receptor for advanced glycosylation end products
9FH10Vertebrata (clade)receptor for advanced glycosylation end products
7GF4ZOpisthokonta (clade)receptor for advanced glycosylation end products
H541HBilateria (clade)receptor for advanced glycosylation end products
CQ2VBMuridae (family)receptor for advanced glycosylation end products
ADZZ4Murinae (subfamily)receptor for advanced glycosylation end products

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: