Domains within Homo sapiens protein CHADL_HUMAN (Q6NUI6)

Chondroadherin-like protein

Alternative representations: 1 /

Protein length762 aa
Source databaseUniProt
Identifiers CHADL_HUMAN, Q6NUI6, ENSP00000216241.9, ENSP00000216241, Q05CY2, Q4G0S0, Q5JY13, Q86XY1, Q96E60
Source gene ENSG00000100399
Alternative splicing H0Y4I5_HUMAN, CHADL_HUMAN, B0QYT2_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eutheria

Predicted functional partners

CHADL_HUMAN is shown as CHADL in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for CHADL

Protein CHADL_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04935Growth hormone synthesis, secretion and action
map04514Cell adhesion molecules

KEGG orthologous groups

KONameDescription
K22038LRRC8volume-regulated anion channel
K25758CHADLchondroadherin-like protein

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000216241 in eggNOG.

OGTaxonomic classDescription
LCOG1552All organisms (root)volume-regulated anion channel,leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein,protein phosphatase 1 regulatory subunit 7
KOG0619Eukaryota (superkingdom)volume-regulated anion channel,leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein,leucine-rich repeat transmembrane protein FLRT
HUIFGMetazoa (kingdom)chondroadherin-like protein
93W4BChordata (phylum)chondroadherin-like protein
5QZ75Sarcopterygii (superclass)chondroadherin-like protein
8Z1R3Mammalia (class)chondroadherin-like protein
4RH75Euarchontoglires (superorder)chondroadherin-like protein
501SEPrimates (order)chondroadherin-like protein
9856BHaplorrhini (suborder)chondroadherin-like protein
BVHV3Simiiformes (infraorder)chondroadherin-like protein
9ER11Catarrhini (parvorder)chondroadherin-like protein
H4SCQBilateria (clade)chondroadherin-like protein
7NCNUOpisthokonta (clade)chondroadherin-like protein,insulin-like growth factor-binding protein complex acid labile subunit
9GGCTVertebrata (clade)chondroadherin-like protein

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: