Domains within Rattus norvegicus protein FGR_RAT (Q6P6U0)
Tyrosine-protein kinase Fgr
Alternative representations: 1 /
| Protein length | 517 aa |
|---|---|
| Source database | UniProt |
| Identifiers | FGR_RAT, Q6P6U0, ENSRNOP00000013779.3, ENSRNOP00000013779, ENSRNOP00000075272.1, ENSRNOP00000075272, Q63206 |
| Source gene | ENSRNOG00000009912 |
Domain architecture analysis
Display all proteins with similar:
| Domain organisation | Proteins having all the domains as the query in the same order. Additional domains are allowed. |
|---|---|
| Domain composition | Proteins with the same domain composition have at least one copy of each of the domains of the query. |
This domain architecture was probably invented with the emergence of Metazoa
Predicted functional partners
FGR_RAT is shown as 
Fgr in the network
Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.
The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.
Protein FGR_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:
KEGG pathways
| Pathway | Description | |
|---|---|---|
| map05416 | Viral myocarditis | |
| map05120 | Epithelial cell signaling in Helicobacter pylori infection | |
| map04360 | Axon guidance | |
| map04062 | Chemokine signaling pathway |
KEGG orthologous groups
| KO | Name | Description | |
|---|---|---|---|
| K08895 | SRMS | tyrosine-protein kinase Srms [EC:2.7.10.2] | |
| K05728 | CSK | c-src tyrosine kinase [EC:2.7.10.2] | |
| K05704 | SRC | tyrosine-protein kinase Src [EC:2.7.10.2] | |
| K08852 | ERN1 | serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-] | |
| K05703 | FYN | tyrosine-protein kinase Fyn [EC:2.7.10.2] | |
| K08891 | FGR, SRC2 | tyrosine-protein kinase Fgr [EC:2.7.10.2] | |
| K08892 | FRK, PTK5 | fyn-related kinase [EC:2.7.10.2] |
Post-translational modifications
PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 25 PTMs annotated in this protein:
| PTM | Count | |
|---|---|---|
 | Phosphorylation | 23 |
 | Ubiquitination | 2 |
To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Fgr.
Orthologous groups
Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000013779 in eggNOG.
| OG | Taxonomic class | Description |
|---|---|---|
| LCOG0478 | All organisms (root) | serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-],RAC serine/threonine-protein kinase [EC:2.7.11.1],pto-interacting protein 1 [EC:2.7.11.1] |
| KOG0197 | Eukaryota (superkingdom) | fyn-related kinase [EC:2.7.10.2],c-src tyrosine kinase [EC:2.7.10.2],Janus kinase 2 [EC:2.7.10.2] |
| HSSCZ | Metazoa (kingdom) | fyn-related kinase [EC:2.7.10.2],tyrosine-protein kinase Src [EC:2.7.10.2],tyrosine-protein kinase Yes [EC:2.7.10.2] |
| 94SPM | Chordata (phylum) | tyrosine-protein kinase Fyn [EC:2.7.10.2],tyrosine-protein kinase Srms [EC:2.7.10.2],protein tyrosine kinase 6 [EC:2.7.10.2] |
| 5QQN7 | Sarcopterygii (superclass) | tyrosine-protein kinase Srms [EC:2.7.10.2],tyrosine-protein kinase Fyn [EC:2.7.10.2],tyrosine-protein kinase Fgr [EC:2.7.10.2] |
| 8ZI94 | Mammalia (class) | tyrosine-protein kinase Fgr [EC:2.7.10.2] |
| 4R46I | Euarchontoglires (superorder) | tyrosine-protein kinase Fgr [EC:2.7.10.2] |
| AHX9W | Rodentia (order) | tyrosine-protein kinase Fgr [EC:2.7.10.2] |
| 8DDM5 | Myomorpha (suborder) | tyrosine-protein kinase Fgr [EC:2.7.10.2] |
| 9FM48 | Vertebrata (clade) | tyrosine-protein kinase Fyn [EC:2.7.10.2],tyrosine-protein kinase Srms [EC:2.7.10.2],protein tyrosine kinase 6 [EC:2.7.10.2] |
| H5CVP | Bilateria (clade) | tyrosine-protein kinase Src [EC:2.7.10.2],fyn-related kinase [EC:2.7.10.2],tyrosine-protein kinase Yes [EC:2.7.10.2] |
| 7IBRR | Opisthokonta (clade) | c-src tyrosine kinase [EC:2.7.10.2],fyn-related kinase [EC:2.7.10.2],tyrosine-protein kinase Src [EC:2.7.10.2] |
| CQAU5 | Muridae (family) | tyrosine-protein kinase Fgr [EC:2.7.10.2] |
| ADZ5Y | Murinae (subfamily) | tyrosine-protein kinase Fgr [EC:2.7.10.2] |
The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.