Domains within Rattus norvegicus protein ANGL4_RAT (Q6TMA8)

Angiopoietin-related protein 4

Alternative representations: 1 /

Protein length405 aa
Source databaseUniProt
Identifiers ANGL4_RAT, Q6TMA8, ENSRNOP00000010031.3, ENSRNOP00000010031
Source gene ENSRNOG00000007545

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Bilateria

Predicted functional partners

ANGL4_RAT is shown as Angptl4 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Angptl4

Protein ANGL4_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map03320PPAR signaling pathway
map04151PI3K-Akt signaling pathway
map04979Cholesterol metabolism

KEGG orthologous groups

KONameDescription
K10104FCNficolin
K08767ANGPTL4, PGARangiopoietin-like 4
K06252TNtenascin

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000010031 in eggNOG.

OGTaxonomic classDescription
LKOG2579All organisms (root)tenascin,ficolin,microfibrillar-associated protein 4
KOG2579Eukaryota (superkingdom)tenascin,ficolin,microfibrillar-associated protein 4
HSZQMMetazoa (kingdom)angiopoietin-like 4,ficolin
94QKQChordata (phylum)angiopoietin-like 4
5QC2JSarcopterygii (superclass)angiopoietin-like 4
8ZG8HMammalia (class)angiopoietin-like 4
4R7GIEuarchontoglires (superorder)angiopoietin-like 4
AHYBBRodentia (order)angiopoietin-like 4
8DE47Myomorpha (suborder)angiopoietin-like 4
7I6DNOpisthokonta (clade)ficolin,microfibrillar-associated protein 4,fibroleukin
9FCCGVertebrata (clade)angiopoietin-like 4
H69K6Bilateria (clade)angiopoietin-like 4
CPZ7CMuridae (family)angiopoietin-like 4
AEAPCMurinae (subfamily)angiopoietin-like 4

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: