Domains within Drosophila melanogaster protein X2JC00_DROME (X2JC00)

Rho GTPase activating protein at 1A, isoform E

Alternative representations: 1 /

Protein length1404 aa
Source databaseUniProt
Identifiers X2JC00_DROME, X2JC00, FBPP0309061, Q8MSA6_DROME, Q8MSA6, Q6W453_DROME, Q6W453
Source gene FBgn0025836
Alternative splicing C1C560_DROME, X2JC00_DROME, Q29QE1_DROME, X2J9V9_DROME

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Coelomata

Predicted functional partners

X2JC00_DROME is shown as RhoGAP1A in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for RhoGAP1A

Protein X2JC00_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05200Pathways in cancer

KEGG orthologous groups

KONameDescription
K08878BCR1, BCRbreakpoint cluster region protein [EC:2.7.11.1]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0309061 in eggNOG.

OGTaxonomic classDescription
EJ9KIEndopterygota (cohort)active breakpoint cluster region-related protein
FV2T6melanogaster group (species group)active breakpoint cluster region-related protein
FE1HKmelanogaster subgroup (species subgroup)active breakpoint cluster region-related protein
LKOG4269All organisms (root)breakpoint cluster region protein [EC:2.7.11.1],active breakpoint cluster region-related protein,RalA-binding protein 1
KOG4269Eukaryota (superkingdom)breakpoint cluster region protein [EC:2.7.11.1],active breakpoint cluster region-related protein,RalA-binding protein 1
HVDCIMetazoa (kingdom)breakpoint cluster region protein [EC:2.7.11.1],active breakpoint cluster region-related protein
HIE76Arthropoda (phylum)active breakpoint cluster region-related protein
8625WHexapoda (subphylum)active breakpoint cluster region-related protein
AH82PNeoptera (infraclass)active breakpoint cluster region-related protein
ANTPIDiptera (order)active breakpoint cluster region-related protein
7NEMROpisthokonta (clade)breakpoint cluster region protein [EC:2.7.11.1],active breakpoint cluster region-related protein
H46IABilateria (clade)breakpoint cluster region protein [EC:2.7.11.1],active breakpoint cluster region-related protein
EH4W5Drosophila (genus)active breakpoint cluster region-related protein
50J43Sophophora (subgenus)active breakpoint cluster region-related protein

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: