Domains within Danio rerio protein Q7SX78_DANRE (Q7SX78)

Sizzled

Alternative representations: 1 /

Protein length282 aa
Source databaseUniProt
Identifiers Q7SX78_DANRE, Q7SX78, ENSDARP00000133257.1, ENSDARP00000133257, Q504J9_DANRE, Q504J9
Source gene ENSDARG00000099637

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eumetazoa

Predicted functional partners

Q7SX78_DANRE is shown as szl in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for szl

Protein Q7SX78_DANRE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04310Wnt signaling pathway

KEGG orthologous groups

KONameDescription
K02432FZD1_7, fzfrizzled 1/7
K02166SFRP1secreted frizzled-related protein 1

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7955.ENSDARP00000133257 in eggNOG.

OGTaxonomic classDescription
9IAW5Otomorpha (cohort)secreted Xwnt8 inhibitor sizzled
LKOG3577All organisms (root)frizzled 1/7,frizzled 9/10,frizzled 5/8
KOG3577Eukaryota (superkingdom)frizzled 1/7,frizzled 9/10,frizzled 5/8
HV740Metazoa (kingdom)frizzled 1/7,frizzled 9/10,frizzled 5/8
94JEDChordata (phylum)secreted frizzled-related protein 5,secreted frizzled-related protein 1,secreted Xwnt8 inhibitor sizzled
FYA0BActinopterygii (superclass)secreted Xwnt8 inhibitor sizzled
8NTRYNeopterygii (subclass)secreted Xwnt8 inhibitor sizzled
7HR05Opisthokonta (clade)frizzled 1/7,frizzled 9/10,frizzled 5/8
H5SBXBilateria (clade)frizzled 1/7,frizzled 9/10,frizzled 5/8
9G8TVVertebrata (clade)secreted frizzled-related protein 5,secreted frizzled-related protein 1,secreted Xwnt8 inhibitor sizzled
BEZGJCyprinidae (family)secreted Xwnt8 inhibitor sizzled

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: