Domains within Coturnix japonica protein Q8AYH0_COTJA (Q8AYH0)

Estrogen receptor

Alternative representations: 1 /

Protein length589 aa
Source databaseUniProt
Identifiers T1VZZ0_COTCO, T1VZZ0, Q8AYH0_COTJA, Q8AYH0

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Metazoa

Predicted functional partners

Q8AYH0_COTJA is shown as ESR1 in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for ESR1

Protein Q8AYH0_COTJA is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05224Breast cancer
map05200Pathways in cancer

KEGG orthologous groups

KONameDescription
K08551ESR2, NR3A2estrogen receptor beta
K08554NR3B3, ESRRGestrogen-related receptor gamma
K08550ESR1, NR3A1estrogen receptor alpha

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 93934.ENSCJPP00005008445 in eggNOG.

OGTaxonomic classDescription
LKOG3575All organisms (root)estrogen-related receptor gamma,nuclear receptor subfamily 2 group E member 3,retinoid X receptor alpha
KOG3575Eukaryota (superkingdom)estrogen-related receptor gamma,nuclear receptor subfamily 2 group E member 3,retinoid X receptor alpha
HSY6YMetazoa (kingdom)estrogen receptor beta,estrogen receptor alpha
94KTDChordata (phylum)estrogen receptor beta,estrogen receptor alpha
5QX6JSarcopterygii (superclass)estrogen receptor alpha
6BIREAves (class)estrogen receptor alpha
8RGMKNeognathae (infraclass)estrogen receptor alpha
BJ385Galloanserae (superorder)estrogen receptor alpha
AIT25Galliformes (order)estrogen receptor alpha
H3VZYBilateria (clade)estrogen receptor beta,estrogen receptor alpha
7K4IYOpisthokonta (clade)estrogen receptor beta,estrogen receptor alpha
9FBYUVertebrata (clade)estrogen receptor beta,estrogen receptor alpha
86V8YPhasianidae (family)estrogen receptor alpha

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: