Domains within Mus musculus protein H2A1H_MOUSE (Q8CGP6)

Histone H2A type 1-H

Alternative representations: 1 /

Protein length128 aa
Source databaseUniProt
Identifiers H2A1H_MOUSE, Q8CGP6, ENSMUSP00000089336.4, ENSMUSP00000089336, A0AUV1_MOUSE, A0AUV1, A0A1A6HTU4_NEOLE, A0A1A6HTU4, A3KPD0_MOUSE, A3KPD0
Source gene ENSMUSG00000069302

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

H2A1H_MOUSE is shown as H2ac12 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for H2ac12

Protein H2A1H_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04217Necroptosis
map05034Alcoholism

KEGG orthologous groups

KONameDescription
K11251H2Ahistone H2A

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 2 PTMs annotated in this protein:

PTMCount
Methylation1
Ubiquitination1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Hist1h2ah.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000089336 in eggNOG.

OGTaxonomic classDescription
7553CAll organisms (root)histone H2A,pleckstrin homology domain-containing family A member 1/2,histone H1/5
KOG1756Eukaryota (superkingdom)histone H2A,pleckstrin homology domain-containing family A member 1/2,histone H1/5
HUBAGMetazoa (kingdom)histone H2A,histone H1/5,mature T-cell proliferation-1 type B1
94F7PChordata (phylum)histone H2A,histone H2B,histone H3
5QRDXSarcopterygii (superclass)histone H2A,histone H3
8ZITMMammalia (class)histone H2A,histone H3
4RKD8Euarchontoglires (superorder)histone H2A
AHY7YRodentia (order)histone H2A
8DIT8Myomorpha (suborder)histone H2A
7GT9HOpisthokonta (clade)histone H2A,histone H1/5,mature T-cell proliferation-1 type B1
9FN6XVertebrata (clade)histone H2A,histone H2B,histone H3
H5NMXBilateria (clade)histone H2A,histone H1/5,mature T-cell proliferation-1 type B1
CQ61EMuridae (family)histone H2A
AE5D4Murinae (subfamily)histone H2A
5PT6TMus (genus)histone H2A
HED41Mus (subgenus)histone H2A

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: