Domains within Drosophila melanogaster protein PANG2_DROME (Q8IMA8)

Protein pangolin, isoform J

Alternative representations: 1 /

Protein length1192 aa
Source databaseUniProt
Identifiers PANG2_DROME, Q8IMA8, FBPP0111569
Source gene FBgn0085432
Alternative splicing H9XVM0_DROME, PANG1_DROME, P91943-6, P91943-4, PANG2_DROME, P91943-5

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

PANG2_DROME is shown as pan in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for pan

Protein PANG2_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05225Hepatocellular carcinoma

KEGG orthologous groups

KONameDescription
K04491TCF7L2transcription factor 7-like 2

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 7 PTMs annotated in this protein:

PTMCount
Ubiquitination4
Phosphorylation3

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein CG32005.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0111569 in eggNOG.

OGTaxonomic classDescription
EIIS5Endopterygota (cohort)transcription factor 7-like 2
LKOG3248All organisms (root)transcription factor 7-like 2,transcription factor 7-like 1,lymphoid enhancer-binding factor 1
FE5D4melanogaster subgroup (species subgroup)transcription factor 7-like 2
FV4M2melanogaster group (species group)transcription factor 7-like 2
KOG3248Eukaryota (superkingdom)transcription factor 7-like 2,transcription factor 7-like 1,lymphoid enhancer-binding factor 1
HW8PIMetazoa (kingdom)transcription factor 7-like 2,transcription factor 7-like 1,lymphoid enhancer-binding factor 1
HIFMHArthropoda (phylum)transcription factor 7-like 2
865J1Hexapoda (subphylum)transcription factor 7-like 2
AHD72Neoptera (infraclass)transcription factor 7-like 2
ANQAJDiptera (order)transcription factor 7-like 2
7IAY5Opisthokonta (clade)transcription factor 7-like 2,transcription factor 7-like 1,lymphoid enhancer-binding factor 1
H48VNBilateria (clade)transcription factor 7-like 2,transcription factor 7-like 1,lymphoid enhancer-binding factor 1
EGZBNDrosophila (genus)transcription factor 7-like 2
50HWJSophophora (subgenus)transcription factor 7-like 2

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: