Domains within Homo sapiens protein AN13A_HUMAN (Q8IZ07)

Ankyrin repeat domain-containing protein 13A

Alternative representations: 1 /

Protein length590 aa
Source databaseUniProt
Identifiers AN13A_HUMAN, Q8IZ07, ENSP00000261739.4, ENSP00000261739, O60736, Q3ZTS7_HUMAN, Q3ZTS7, H2Q6V1_PANTR, H2Q6V1, H2NIL7_PONAB, H2NIL7, B4DDL0_HUMAN, B4DDL0
Source gene ENSG00000076513
Alternative splicing S4R3D2_HUMAN, AN13A_HUMAN, H0YIN8_HUMAN, S4R3U2_HUMAN, ENSP00000447110.2

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Euteleostomi

Predicted functional partners

AN13A_HUMAN is shown as ANKRD13A in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for ANKRD13A

Protein AN13A_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04810Regulation of actin cytoskeleton

KEGG orthologous groups

KONameDescription
K21437ANKRD13ankyrin repeat domain-containing protein 13

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 46 PTMs annotated in this protein:

PTMCount
Ubiquitination26
Phosphorylation16
Acetylation4

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein ENSPTRG00000005434.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000261739 in eggNOG.

OGTaxonomic classDescription
LKOG0522All organisms (root)ankyrin repeat domain-containing protein 13,protein phosphatase slingshot [EC:3.1.3.16 3.1.3.48]
KOG0522Eukaryota (superkingdom)ankyrin repeat domain-containing protein 13,protein phosphatase slingshot [EC:3.1.3.16 3.1.3.48]
HW4YSMetazoa (kingdom)ankyrin repeat domain-containing protein 13
93KZPChordata (phylum)ankyrin repeat domain-containing protein 13
5R4ZZSarcopterygii (superclass)ankyrin repeat domain-containing protein 13
8ZMWWMammalia (class)ankyrin repeat domain-containing protein 13
4R3I5Euarchontoglires (superorder)ankyrin repeat domain-containing protein 13
4ZXIFPrimates (order)ankyrin repeat domain-containing protein 13
98DJAHaplorrhini (suborder)ankyrin repeat domain-containing protein 13
BVC9RSimiiformes (infraorder)ankyrin repeat domain-containing protein 13
9EI01Catarrhini (parvorder)ankyrin repeat domain-containing protein 13
H3TT7Bilateria (clade)ankyrin repeat domain-containing protein 13
9G78YVertebrata (clade)ankyrin repeat domain-containing protein 13
7H97WOpisthokonta (clade)ankyrin repeat domain-containing protein 13
FX25XHominoidea (superfamily)ankyrin repeat domain-containing protein 13
5N956Hominidae (family)ankyrin repeat domain-containing protein 13
5Y83IHomininae (subfamily)ankyrin repeat domain-containing protein 13

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: