Domains within Homo sapiens protein HEY1_HUMAN (Q9Y5J3)

Hairy/enhancer-of-split related with YRPW motif protein 1

Alternative representations: 1 /

Protein length304 aa
Source databaseUniProt
Identifiers HEY1_HUMAN, Q9Y5J3, ENSP00000346761.3, ENSP00000346761, B2R883, Q5TZS3, Q8NAM2, Q9NYP4, K7D7U5_PANTR, K7D7U5, H2PQM4_PONAB, H2PQM4, E5RHK6_HUMAN, E5RHK6, A0A2J8V9X2_PONAB, A0A2J8V9X2, A0A2J8M9X6_PANTR, A0A2J8M9X6
Source gene ENSG00000164683
Alternative splicing HEY1_HUMAN, ENSP00000338272.5, B4DEI9_HUMAN, ENSP00000429705.1

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Coelomata

Predicted functional partners

HEY1_HUMAN is shown as HEY1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for HEY1

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9598.ENSPTRP00000069126 in eggNOG.

OGTaxonomic classDescription
LKOG4304All organisms (root)hairy and enhancer of split 2/6/7,hairy and enhancer of split related with YRPW motif,hairy and enhancer of split 5
KOG4304Eukaryota (superkingdom)hairy and enhancer of split 2/6/7,hairy and enhancer of split related with YRPW motif,hairy and enhancer of split 5
HUCGZMetazoa (kingdom)hairy and enhancer of split related with YRPW motif,class B basic helix-loop-helix protein 3,NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 7
9411CChordata (phylum)hairy and enhancer of split related with YRPW motif
5QFV9Sarcopterygii (superclass)hairy and enhancer of split related with YRPW motif
8ZIZYMammalia (class)hairy and enhancer of split related with YRPW motif
4RE9EEuarchontoglires (superorder)hairy and enhancer of split related with YRPW motif
501ICPrimates (order)hairy and enhancer of split related with YRPW motif
98B48Haplorrhini (suborder)hairy and enhancer of split related with YRPW motif
BVIACSimiiformes (infraorder)hairy and enhancer of split related with YRPW motif
9EG16Catarrhini (parvorder)hairy and enhancer of split related with YRPW motif
7GUPUOpisthokonta (clade)hairy and enhancer of split related with YRPW motif,class B basic helix-loop-helix protein 3,NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 7
9GKE7Vertebrata (clade)hairy and enhancer of split related with YRPW motif
H6P38Bilateria (clade)hairy and enhancer of split related with YRPW motif
FX7FKHominoidea (superfamily)hairy and enhancer of split related with YRPW motif
5N4PDHominidae (family)hairy and enhancer of split related with YRPW motif
5Y58WHomininae (subfamily)hairy and enhancer of split related with YRPW motif

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: