Domains within Homo sapiens protein GMCL2_HUMAN (Q8NEA9)

Germ cell-less protein-like 2

Alternative representations: 1 /

Protein length526 aa
Source databaseUniProt
Identifiers B2RDW6, Q2VIQ8, Q8TC88, Q8TC89, GMCL2_HUMAN, Q8NEA9

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

GMCL2_HUMAN is shown as GMCL2 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for GMCL2

Protein GMCL2_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map03040Spliceosome

KEGG orthologous groups

KONameDescription
K10485BTBD13, GMCL1, GCLBTB/POZ domain-containing protein 13 (germ cell-less protein-like 1)

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000497178 in eggNOG.

OGTaxonomic classDescription
LKOG4682All organisms (root)BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1),BTB/POZ domain-containing protein 16,annexin A4
KOG4682Eukaryota (superkingdom)BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1),BTB/POZ domain-containing protein 16,annexin A4
HTF8ZMetazoa (kingdom)BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1),annexin A4,U4/U6.U5 tri-snRNP-associated protein 3
93ZE2Chordata (phylum)BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1),annexin A4,U4/U6.U5 tri-snRNP-associated protein 3
5QXWSSarcopterygii (superclass)BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1),annexin A4,U4/U6.U5 tri-snRNP-associated protein 3
8Z8I7Mammalia (class)BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1),annexin A4,U4/U6.U5 tri-snRNP-associated protein 3
4RN6TEuarchontoglires (superorder)BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1),annexin A4,U4/U6.U5 tri-snRNP-associated protein 3
500MXPrimates (order)BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1)
98QK0Haplorrhini (suborder)BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1)
BVJ7RSimiiformes (infraorder)BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1)
9EKSMCatarrhini (parvorder)BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1)
H5XUJBilateria (clade)BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1),annexin A4,U4/U6.U5 tri-snRNP-associated protein 3
9G1IDVertebrata (clade)BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1),annexin A4,U4/U6.U5 tri-snRNP-associated protein 3
7HQH9Opisthokonta (clade)BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1),annexin A4,U4/U6.U5 tri-snRNP-associated protein 3
FX2IXHominoidea (superfamily)BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1)
5N825Hominidae (family)BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1)
5XUNZHomininae (subfamily)BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1)

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: