Domains within Drosophila melanogaster protein PUF68_DROME (Q8T6B9)

Poly(U)-binding-splicing factor half pint

Alternative representations: 1 /

Protein length637 aa
Source databaseUniProt
Identifiers PUF68_DROME, Q8T6B9, FBPP0072593, Q0E8J8, Q95S11, Q9U696, Q9W0E6, Q9W0E7, A4V193_DROME, A4V193, Q8T6B9-2
Source gene FBgn0028577
Alternative splicing FBpp0289645, PUF68_DROME

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

PUF68_DROME is shown as hfp in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for hfp

Protein PUF68_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map03040Spliceosome

KEGG orthologous groups

KONameDescription
K12838PUF60poly(U)-binding-splicing factor PUF60

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 6 PTMs annotated in this protein:

PTMCount
Phosphorylation5
Ubiquitination1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein pUf68.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0072593 in eggNOG.

OGTaxonomic classDescription
FDV2Imelanogaster subgroup (species subgroup)poly(U)-binding-splicing factor PUF60
FV61Tmelanogaster group (species group)poly(U)-binding-splicing factor PUF60
EIHKQEndopterygota (cohort)poly(U)-binding-splicing factor PUF60
LKOG0124All organisms (root)poly(U)-binding-splicing factor PUF60
KOG0124Eukaryota (superkingdom)poly(U)-binding-splicing factor PUF60
HU0DAMetazoa (kingdom)poly(U)-binding-splicing factor PUF60
HISECArthropoda (phylum)poly(U)-binding-splicing factor PUF60
85E9VHexapoda (subphylum)poly(U)-binding-splicing factor PUF60
AH80TNeoptera (infraclass)poly(U)-binding-splicing factor PUF60
ANNI8Diptera (order)poly(U)-binding-splicing factor PUF60
7KTF2Opisthokonta (clade)poly(U)-binding-splicing factor PUF60
H745RBilateria (clade)poly(U)-binding-splicing factor PUF60
EH574Drosophila (genus)poly(U)-binding-splicing factor PUF60
50G8DSophophora (subgenus)poly(U)-binding-splicing factor PUF60

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: