Domains within Mus musculus protein PRGC2_MOUSE (Q8VHJ7)

Peroxisome proliferator-activated receptor gamma coactivator 1-beta

Alternative representations: 1 /

Protein length1014 aa
Source databaseUniProt
Identifiers PRGC2_MOUSE, Q8VHJ7, ENSMUSP00000074771.6, ENSMUSP00000074771, Q8C1C0
Source gene ENSMUSG00000033871
Alternative splicing PRGC2_MOUSE, Q8VHJ7-2

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

PRGC2_MOUSE is shown as Ppargc1b in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Ppargc1b

Protein PRGC2_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04931Insulin resistance

KEGG orthologous groups

KONameDescription
K17962PPARGC1B, PGC1Bperoxisome proliferator-activated receptor gamma coactivator 1-beta

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000074771 in eggNOG.

OGTaxonomic classDescription
71VFQAll organisms (root)peroxisome proliferator-activated receptor gamma coactivator 1-beta
5JX1REukaryota (superkingdom)peroxisome proliferator-activated receptor gamma coactivator 1-beta
HTSH4Metazoa (kingdom)peroxisome proliferator-activated receptor gamma coactivator 1-beta
93VJMChordata (phylum)peroxisome proliferator-activated receptor gamma coactivator 1-beta
5QT6WSarcopterygii (superclass)peroxisome proliferator-activated receptor gamma coactivator 1-beta
8Z8ACMammalia (class)peroxisome proliferator-activated receptor gamma coactivator 1-beta
4RC4YEuarchontoglires (superorder)peroxisome proliferator-activated receptor gamma coactivator 1-beta
AI4FRRodentia (order)peroxisome proliferator-activated receptor gamma coactivator 1-beta
8DKQ9Myomorpha (suborder)peroxisome proliferator-activated receptor gamma coactivator 1-beta
7GQVKOpisthokonta (clade)peroxisome proliferator-activated receptor gamma coactivator 1-beta
H5XKWBilateria (clade)peroxisome proliferator-activated receptor gamma coactivator 1-beta
9FT75Vertebrata (clade)peroxisome proliferator-activated receptor gamma coactivator 1-beta
CQDJBMuridae (family)peroxisome proliferator-activated receptor gamma coactivator 1-beta
AECW6Murinae (subfamily)peroxisome proliferator-activated receptor gamma coactivator 1-beta
5PQFYMus (genus)peroxisome proliferator-activated receptor gamma coactivator 1-beta
HDZWTMus (subgenus)peroxisome proliferator-activated receptor gamma coactivator 1-beta

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: