Domains within Rattus norvegicus protein FGF23_RAT (Q8VI82)

Fibroblast growth factor 23

Alternative representations: 1 /

Protein length251 aa
Source databaseUniProt
Identifiers FGF23_RAT, Q8VI82, ENSRNOP00000075536.1, ENSRNOP00000075536
Source gene ENSRNOG00000052205

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Bilateria

Predicted functional partners

FGF23_RAT is shown as Fgf23 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Fgf23

Protein FGF23_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05224Breast cancer
map04020Calcium signaling pathway

KEGG orthologous groups

KONameDescription
K04358FGFfibroblast growth factor
K22428FGF23fibroblast growth factor 23

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000075536 in eggNOG.

OGTaxonomic classDescription
LKOG3885All organisms (root)fibroblast growth factor,fibroblast growth factor 11/12/13,fibroblast growth factor 1
KOG3885Eukaryota (superkingdom)fibroblast growth factor,fibroblast growth factor 11/12/13,fibroblast growth factor 1
HW7JGMetazoa (kingdom)fibroblast growth factor 23
94VQWChordata (phylum)fibroblast growth factor 23
5QNVWSarcopterygii (superclass)fibroblast growth factor 23
8ZBQKMammalia (class)fibroblast growth factor 23
4RKGZEuarchontoglires (superorder)fibroblast growth factor 23
AIGMFRodentia (order)fibroblast growth factor 23
8DDWBMyomorpha (suborder)fibroblast growth factor 23
9GI2SVertebrata (clade)fibroblast growth factor 23
H5S2GBilateria (clade)fibroblast growth factor 23
7MGPXOpisthokonta (clade)fibroblast growth factor 23
CQ7CTMuridae (family)fibroblast growth factor 23
AE72FMurinae (subfamily)fibroblast growth factor 23

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: