Domains within Mus musculus protein DLG2_MOUSE (Q91XM9)
Disks large homolog 2
Alternative representations: 1 /
| Protein length | 852 aa |
|---|---|
| Source database | UniProt |
| Identifiers | DLG2_MOUSE, Q91XM9, ENSMUSP00000102814.2, ENSMUSP00000102814, F8VQM7, Q8BXK7, Q8BYG5 |
| Source gene | ENSMUSG00000052572 |
| Alternative splicing | DLG2_MOUSE, E9Q2L2_MOUSE, D3YUZ8_MOUSE, D3YWU0_MOUSE |
Domain architecture analysis
Display all proteins with similar:
| Domain organisation | Proteins having all the domains as the query in the same order. Additional domains are allowed. |
|---|---|
| Domain composition | Proteins with the same domain composition have at least one copy of each of the domains of the query. |
Predicted functional partners
DLG2_MOUSE is shown as 
Dlg2 in the network
Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.
The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.
Protein DLG2_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:
KEGG pathways
| Pathway | Description | |
|---|---|---|
| map04390 | Hippo signaling pathway |
KEGG orthologous groups
| KO | Name | Description | |
|---|---|---|---|
| K12076 | DLG1 | disks large protein 1 | |
| K24050 | DLG5 | discs large protein 5 | |
| K12075 | DLG2 | discs large protein 2 | |
| K00942 | gmk, GUK1 | guanylate kinase [EC:2.7.4.8] | iPath3 |
Orthologous groups
Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000102814 in eggNOG.
| OG | Taxonomic class | Description |
|---|---|---|
| LCOG0194 | All organisms (root) | guanylate kinase [EC:2.7.4.8],MAGUK p55 subfamily member 2/6,MAGUK p55 subfamily member 3/7 |
| KOG0708 | Eukaryota (superkingdom) | discs large protein 5,disks large protein 1,caspase recruitment domain-containing protein 11 |
| HTZS8 | Metazoa (kingdom) | disks large protein 1,discs large protein 2,discs large protein 4 |
| 94FU9 | Chordata (phylum) | disks large protein 1,discs large protein 2,discs large protein 4 |
| 5RDF6 | Sarcopterygii (superclass) | discs large protein 2,disks large protein 1,discs large protein 3 |
| 8ZKRK | Mammalia (class) | discs large protein 2,disks large protein 1,melanoma-associated antigen p97 |
| 4RR1V | Euarchontoglires (superorder) | discs large protein 2,disks large protein 1,melanoma-associated antigen p97 |
| AIDRC | Rodentia (order) | discs large protein 2,disks large protein 1,melanoma-associated antigen p97 |
| 8DKDN | Myomorpha (suborder) | discs large protein 2,disks large protein 1,melanoma-associated antigen p97 |
| 9FQ8Y | Vertebrata (clade) | disks large protein 1,discs large protein 2,discs large protein 4 |
| H4K40 | Bilateria (clade) | disks large protein 1,discs large protein 2,discs large protein 4 |
| 7H0PC | Opisthokonta (clade) | disks large protein 1,discs large protein 2,discs large protein 4 |
| CQ2XS | Muridae (family) | discs large protein 2 |
| AEA7M | Murinae (subfamily) | discs large protein 2 |
| 5PVJI | Mus (genus) | discs large protein 2 |
| HEFW2 | Mus (subgenus) | discs large protein 2 |
The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.