Domains within Homo sapiens protein H1X_HUMAN (Q92522)

Histone H1x

Alternative representations: 1 /

Protein length213 aa
Source databaseUniProt
Identifiers H1X_HUMAN, Q92522, ENSP00000329662.4, ENSP00000329662
Source gene ENSG00000184897

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

H1X_HUMAN is shown as H1-10 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for H1-10

Protein H1X_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05146Amoebiasis

KEGG orthologous groups

KONameDescription
K11275H1_5histone H1/5

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 26 PTMs annotated in this protein:

PTMCount
Acetylation11
Phosphorylation6
Ubiquitination5
Methylation4

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein H1FX.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000329662 in eggNOG.

OGTaxonomic classDescription
LKOG4012All organisms (root)histone H1/5,T-cell surface glycoprotein CD1,MHC class I antigen
KOG4012Eukaryota (superkingdom)histone H1/5,T-cell surface glycoprotein CD1,MHC class I antigen
HSXKQMetazoa (kingdom)histone H1/5
93T53Chordata (phylum)histone H1/5
5R7PRSarcopterygii (superclass)histone H1/5
8YUY9Mammalia (class)histone H1/5
4RPYTEuarchontoglires (superorder)histone H1/5
4ZITXPrimates (order)histone H1/5
98J7ZHaplorrhini (suborder)histone H1/5
BVGUNSimiiformes (infraorder)histone H1/5
9EVD3Catarrhini (parvorder)histone H1/5
9FAEXVertebrata (clade)histone H1/5
7JJINOpisthokonta (clade)histone H1/5
H3EA4Bilateria (clade)histone H1/5
FXAB9Hominoidea (superfamily)histone H1/5
5N3USHominidae (family)histone H1/5
5Y1RSHomininae (subfamily)histone H1/5

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: