Domains within Mus musculus protein GRIP1_MOUSE (Q925T6)

Glutamate receptor-interacting protein 1

Alternative representations: 1 /

Protein length1127 aa
Source databaseUniProt
Identifiers GRIP1_MOUSE, Q925T6, ENSMUSP00000123234.1, ENSMUSP00000123234, Q8BLQ3, Q8C0T3, Q925T5, Q925T7
Source gene ENSMUSG00000034813
Alternative splicing Q925T6-2, H7BX09_MOUSE, Q6GQT7_MOUSE, H7BX90_MOUSE, D3YZL8_MOUSE, GRIP1_MOUSE, Q925T6-3, D3YWY4_MOUSE, D3Z6T4_MOUSE, D3Z066_MOUSE, Q925T6-4, D3Z6R6_MOUSE, Q6X4T6_MOUSE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Coelomata

Predicted functional partners

GRIP1_MOUSE is shown as Grip1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Grip1

Protein GRIP1_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04520Adherens junction
map04210Apoptosis

KEGG orthologous groups

KONameDescription
K07817PTPRNreceptor-type tyrosine-protein phosphatase N [EC:3.1.3.48]
K18025PTPN14_21tyrosine-protein phosphatase non-receptor type 14/21 [EC:3.1.3.48]

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 8 PTMs annotated in this protein:

PTMCount
Phosphorylation8

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Grip1.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000123234 in eggNOG.

OGTaxonomic classDescription
LCOG5599All organisms (root)receptor-type tyrosine-protein phosphatase N [EC:3.1.3.48],tyrosine-protein phosphatase non-receptor type 12/18/22 [EC:3.1.3.48],tyrosine-protein phosphatase non-receptor type 14/21 [EC:3.1.3.48]
KOG0792Eukaryota (superkingdom)tyrosine-protein phosphatase non-receptor type 14/21 [EC:3.1.3.48],tyrosine-protein phosphatase non-receptor type 4 [EC:3.1.3.48],tyrosine-protein phosphatase non-receptor type 13
HUZ5WMetazoa (kingdom)glutamate receptor-interacting protein
93DTXChordata (phylum)glutamate receptor-interacting protein
5QCIISarcopterygii (superclass)glutamate receptor-interacting protein
8ZDWKMammalia (class)glutamate receptor-interacting protein
4RNE6Euarchontoglires (superorder)glutamate receptor-interacting protein
AI9N1Rodentia (order)glutamate receptor-interacting protein
8D4KRMyomorpha (suborder)glutamate receptor-interacting protein
7IXNCOpisthokonta (clade)glutamate receptor-interacting protein
H4358Bilateria (clade)glutamate receptor-interacting protein
9G3QTVertebrata (clade)glutamate receptor-interacting protein
CQ0XZMuridae (family)glutamate receptor-interacting protein
ADWYQMurinae (subfamily)glutamate receptor-interacting protein
5PXGUMus (genus)glutamate receptor-interacting protein
HE4SXMus (subgenus)glutamate receptor-interacting protein

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: