Domains within Drosophila melanogaster protein ONEC_DROME (Q9NJB5)

Homeobox protein onecut

Alternative representations: 1 /

Protein length1081 aa
Source databaseUniProt
Identifiers ONEC_DROME, Q9NJB5, FBPP0088173, FBPP0302730, Q9V4E4, L0MPQ0_DROME, L0MPQ0, Q3YND8_DROME, Q3YND8, Q95TW5_DROME, Q95TW5
Source gene FBgn0028996

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

ONEC_DROME is shown as onecut in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for onecut

Protein ONEC_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04550Signaling pathways regulating pluripotency of stem cells

KEGG orthologous groups

KONameDescription
K08026ONECUT1, HNF6one cut domain, family member 1 (hepatocyte nuclear factor 6)

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0088173 in eggNOG.

OGTaxonomic classDescription
LKOG2252All organisms (root)one cut domain, family member 1 (hepatocyte nuclear factor 6),homeobox protein cut-like,one cut domain family member 3
FE54Gmelanogaster subgroup (species subgroup)one cut domain, family member 1 (hepatocyte nuclear factor 6)
FUV64melanogaster group (species group)one cut domain, family member 1 (hepatocyte nuclear factor 6)
EJGQQEndopterygota (cohort)one cut domain, family member 1 (hepatocyte nuclear factor 6)
KOG2252Eukaryota (superkingdom)one cut domain, family member 1 (hepatocyte nuclear factor 6),homeobox protein cut-like,one cut domain family member 3
HSSQ2Metazoa (kingdom)one cut domain, family member 1 (hepatocyte nuclear factor 6),one cut domain family member 3,one cut domain family member 2
HIGHHArthropoda (phylum)one cut domain, family member 1 (hepatocyte nuclear factor 6)
86BNMHexapoda (subphylum)one cut domain, family member 1 (hepatocyte nuclear factor 6)
AHPGCNeoptera (infraclass)one cut domain, family member 1 (hepatocyte nuclear factor 6)
ANWDJDiptera (order)one cut domain, family member 1 (hepatocyte nuclear factor 6)
H57X5Bilateria (clade)one cut domain family member 3,one cut domain family member 2,one cut domain, family member 1 (hepatocyte nuclear factor 6)
7JC2FOpisthokonta (clade)one cut domain, family member 1 (hepatocyte nuclear factor 6),one cut domain family member 3,one cut domain family member 2
EGWMXDrosophila (genus)one cut domain, family member 1 (hepatocyte nuclear factor 6)
50NW7Sophophora (subgenus)one cut domain, family member 1 (hepatocyte nuclear factor 6)

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: