Domains within Drosophila melanogaster protein Q7KNF1_DROME (Q7KNF1)

Drosha

Alternative representations: 1 /

Protein length1327 aa
Source databaseUniProt
Identifiers Q7KNF1_DROME, Q7KNF1, FBPP0087926, Q960Y4_DROME, Q960Y4
Source gene FBgn0026722

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Bilateria

Predicted functional partners

Q7KNF1_DROME is shown as drosha in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for drosha

Protein Q7KNF1_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05205Proteoglycans in cancer

KEGG orthologous groups

KONameDescription
K03685rnc, DROSHA, RNT1ribonuclease III [EC:3.1.26.3]

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 7 PTMs annotated in this protein:

PTMCount
Phosphorylation7

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein drosha.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0087926 in eggNOG.

OGTaxonomic classDescription
LCOG0571All organisms (root)ribonuclease III [EC:3.1.26.3],endoribonuclease Dicer [EC:3.1.26.-],large subunit ribosomal protein L44 [EC:3.1.26.-]
EICKQEndopterygota (cohort)ribonuclease III [EC:3.1.26.3]
FDTW5melanogaster subgroup (species subgroup)ribonuclease III [EC:3.1.26.3]
FV67Xmelanogaster group (species group)ribonuclease III [EC:3.1.26.3]
KOG1817Eukaryota (superkingdom)ribonuclease III [EC:3.1.26.3],large subunit ribosomal protein L32,AT-rich interactive domain-containing protein 1
HWAAHMetazoa (kingdom)ribonuclease III [EC:3.1.26.3],AT-rich interactive domain-containing protein 1
HHZEEArthropoda (phylum)ribonuclease III [EC:3.1.26.3],AT-rich interactive domain-containing protein 1
85MIVHexapoda (subphylum)ribonuclease III [EC:3.1.26.3],AT-rich interactive domain-containing protein 1
AH97PNeoptera (infraclass)ribonuclease III [EC:3.1.26.3],AT-rich interactive domain-containing protein 1
AP37PDiptera (order)ribonuclease III [EC:3.1.26.3]
H5RDIBilateria (clade)ribonuclease III [EC:3.1.26.3],AT-rich interactive domain-containing protein 1
7MH81Opisthokonta (clade)ribonuclease III [EC:3.1.26.3],AT-rich interactive domain-containing protein 1,ubiquitin-conjugating enzyme E2 I
EGWM9Drosophila (genus)ribonuclease III [EC:3.1.26.3]
50C2ISophophora (subgenus)ribonuclease III [EC:3.1.26.3]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: