Domains within Homo sapiens protein KREM1_HUMAN (Q96MU8)

Kremen protein 1

Alternative representations: 1 /

Protein length473 aa
Source databaseUniProt
Identifiers KREM1_HUMAN, Q96MU8, ENSP00000385431.1, ENSP00000385431, B0QY46, B0QY47, B1AJR5, Q5TIB9, Q6P3X6, Q9BY70, Q9UGS5, Q9UGU1, G3QID4_GORGO, G3QID4
Source gene ENSG00000183762
Alternative splicing Q96MU8-3, Q96MU8-2, KREM1_HUMAN, H7BZ87_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Chordata

Predicted functional partners

KREM1_HUMAN is shown as KREMEN1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for KREMEN1

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9593.ENSGGOP00000002140 in eggNOG.

OGTaxonomic classDescription
LKOG4157All organisms (root)centromere protein S,cell wall integrity and stress response component,kremen protein
KOG4157Eukaryota (superkingdom)centromere protein S,cell wall integrity and stress response component,kremen protein
HUDP1Metazoa (kingdom)kremen protein
93V7VChordata (phylum)kremen protein
5RDUCSarcopterygii (superclass)kremen protein
8Z5KNMammalia (class)kremen protein
4RAPIEuarchontoglires (superorder)kremen protein
4ZS58Primates (order)kremen protein
988MQHaplorrhini (suborder)kremen protein
BV6MSSimiiformes (infraorder)kremen protein
9EIIJCatarrhini (parvorder)kremen protein
H69PDBilateria (clade)kremen protein
7N4SYOpisthokonta (clade)centromere protein S,cell wall integrity and stress response component,kremen protein
9FGRWVertebrata (clade)kremen protein
FWZ4WHominoidea (superfamily)kremen protein
5MZQCHominidae (family)kremen protein
5Y96AHomininae (subfamily)kremen protein

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: