Domains within Homo sapiens protein CSMD1_HUMAN (Q96PZ7)

CUB and sushi domain-containing protein 1

Alternative representations: 1 /

Protein length3564 aa
Source databaseUniProt
Identifiers CSMD1_HUMAN, Q96PZ7, ENSP00000489225.1, ENSP00000489225, A0A0U1RQY1, Q0H0J5, Q96QU9, Q96RM4, F5GZ18_HUMAN, F5GZ18
Source gene ENSG00000183117
Alternative splicing H7BXU2_HUMAN, F8W9C3_HUMAN, CSMD1_HUMAN, E5RIG2_HUMAN, ENSP00000441462.2

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Euteleostomi

Predicted functional partners

CSMD1_HUMAN is shown as CSMD1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for CSMD1

Protein CSMD1_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04145Phagosome
map04979Cholesterol metabolism

KEGG orthologous groups

KONameDescription
K17495CSMDCUB and sushi domain-containing protein
K06560MRC, CD206, CD280mannose receptor, C type

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000489225 in eggNOG.

OGTaxonomic classDescription
LKOG4297All organisms (root)mannose receptor, C type,CUB and sushi domain-containing protein,E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27]
KOG4297Eukaryota (superkingdom)mannose receptor, C type,CUB and sushi domain-containing protein,E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27]
HV6G4Metazoa (kingdom)CUB and sushi domain-containing protein
947H4Chordata (phylum)CUB and sushi domain-containing protein
5QTWMSarcopterygii (superclass)CUB and sushi domain-containing protein
8Z0PQMammalia (class)CUB and sushi domain-containing protein
4R3RXEuarchontoglires (superorder)CUB and sushi domain-containing protein
501V4Primates (order)CUB and sushi domain-containing protein
988DCHaplorrhini (suborder)CUB and sushi domain-containing protein
BUZP3Simiiformes (infraorder)CUB and sushi domain-containing protein
9EZ5PCatarrhini (parvorder)CUB and sushi domain-containing protein
9FS40Vertebrata (clade)CUB and sushi domain-containing protein
H3TFXBilateria (clade)CUB and sushi domain-containing protein
7IFIBOpisthokonta (clade)CUB and sushi domain-containing protein,apolipoprotein(a) [EC:3.4.21.-]
FX4SJHominoidea (superfamily)CUB and sushi domain-containing protein
5N1UUHominidae (family)CUB and sushi domain-containing protein
5XX0QHomininae (subfamily)CUB and sushi domain-containing protein

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: