Domains within Homo sapiens protein ATF6B_HUMAN (Q99941)

Cyclic AMP-dependent transcription factor ATF-6 beta

Alternative representations: 1 /

Protein length703 aa
Source databaseUniProt
Identifiers ATF6B_HUMAN, Q99941, ENSP00000404814.2, ENSP00000404814, ENSP00000404725.2, ENSP00000404725, ENSP00000364349.3, ENSP00000364349, ENSP00000293709.6, ENSP00000293709, B0UYX6, Q13269, Q14343, Q14345, Q5SSW7, Q99635, Q99637, Q9H3V9, Q9H3W1, Q9NPL0
Source gene ENSG00000228628
Alternative splicing ATF6B_HUMAN, A0A1U9X796_HUMAN, H0Y7D7_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

ATF6B_HUMAN is shown as ATF6B in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for ATF6B

Protein ATF6B_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04141Protein processing in endoplasmic reticulum
map04926Relaxin signaling pathway

KEGG orthologous groups

KONameDescription
K09054ATF6Acyclic AMP-dependent transcription factor ATF-6 alpha
K09049ATF6B, CREBL1cyclic AMP-dependent transcription factor ATF-6 beta

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 28 PTMs annotated in this protein:

PTMCount
Phosphorylation12
N-linked glycosylation8
O-linked glycosylation8

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein ENSG00000213676.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000364349 in eggNOG.

OGTaxonomic classDescription
LKOG4343All organisms (root)cyclic AMP-dependent transcription factor ATF-6 alpha,cyclic AMP-dependent transcription factor ATF-6 beta,cyclic AMP-responsive element-binding protein 3
KOG4343Eukaryota (superkingdom)cyclic AMP-dependent transcription factor ATF-6 alpha,cyclic AMP-dependent transcription factor ATF-6 beta,cyclic AMP-responsive element-binding protein 3
HUADPMetazoa (kingdom)cyclic AMP-dependent transcription factor ATF-6 alpha,cyclic AMP-dependent transcription factor ATF-6 beta,dual specificity phosphatase 12 [EC:3.1.3.16 3.1.3.48]
947ZCChordata (phylum)cyclic AMP-dependent transcription factor ATF-6 alpha,cyclic AMP-dependent transcription factor ATF-6 beta,dual specificity phosphatase 12 [EC:3.1.3.16 3.1.3.48]
5R4AISarcopterygii (superclass)cyclic AMP-dependent transcription factor ATF-6 beta
8YZRGMammalia (class)cyclic AMP-dependent transcription factor ATF-6 beta
4R73TEuarchontoglires (superorder)cyclic AMP-dependent transcription factor ATF-6 beta
4ZRRYPrimates (order)cyclic AMP-dependent transcription factor ATF-6 beta
985KBHaplorrhini (suborder)cyclic AMP-dependent transcription factor ATF-6 beta
BVBX6Simiiformes (infraorder)cyclic AMP-dependent transcription factor ATF-6 beta
9EK3NCatarrhini (parvorder)cyclic AMP-dependent transcription factor ATF-6 beta
7GQ4GOpisthokonta (clade)cyclic AMP-dependent transcription factor ATF-6 alpha,cyclic AMP-dependent transcription factor ATF-6 beta,dual specificity phosphatase 12 [EC:3.1.3.16 3.1.3.48]
H5D29Bilateria (clade)cyclic AMP-dependent transcription factor ATF-6 alpha,cyclic AMP-dependent transcription factor ATF-6 beta,dual specificity phosphatase 12 [EC:3.1.3.16 3.1.3.48]
9FJITVertebrata (clade)cyclic AMP-dependent transcription factor ATF-6 alpha,cyclic AMP-dependent transcription factor ATF-6 beta,dual specificity phosphatase 12 [EC:3.1.3.16 3.1.3.48]
FX6CRHominoidea (superfamily)cyclic AMP-dependent transcription factor ATF-6 beta
5N0KRHominidae (family)cyclic AMP-dependent transcription factor ATF-6 beta
5XT07Homininae (subfamily)cyclic AMP-dependent transcription factor ATF-6 beta

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: