Domains within Homo sapiens protein SOX7_HUMAN (Q9BT81)

Transcription factor SOX-7

Alternative representations: 1 /

Protein length388 aa
Source databaseUniProt
Identifiers SOX7_HUMAN, Q9BT81, ENSP00000301921.1, ENSP00000301921, ENSP00000495029.1, ENSP00000495029, B4DKV0, Q53YD0
Source gene ENSG00000171056

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

SOX7_HUMAN is shown as SOX7 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for SOX7

Protein SOX7_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04550Signaling pathways regulating pluripotency of stem cells
map04310Wnt signaling pathway

KEGG orthologous groups

KONameDescription
K09270SOX7Stranscription factor SOX7/8/10/18 (SOX group E/F)
K09267SOX1Stranscription factor SOX1/3/14/21 (SOX group B)

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000301921 in eggNOG.

OGTaxonomic classDescription
LKOG0527All organisms (root)transcription factor SOX1/3/14/21 (SOX group B),transcription factor SOX7/8/10/18 (SOX group E/F),transcription factor SOX11/12 (SOX group C)
KOG0527Eukaryota (superkingdom)transcription factor SOX1/3/14/21 (SOX group B),transcription factor SOX7/8/10/18 (SOX group E/F),transcription factor SOX11/12 (SOX group C)
HUI0DMetazoa (kingdom)transcription factor SOX17 (SOX group F),transcription factor SOX7/8/10/18 (SOX group E/F),transcription factor SOX1/3/14/21 (SOX group B)
94SG4Chordata (phylum)transcription factor SOX17 (SOX group F),transcription factor SOX7/8/10/18 (SOX group E/F)
5R7IASarcopterygii (superclass)transcription factor SOX7/8/10/18 (SOX group E/F)
8YV7YMammalia (class)transcription factor SOX7/8/10/18 (SOX group E/F)
4R2TUEuarchontoglires (superorder)transcription factor SOX7/8/10/18 (SOX group E/F)
4ZW47Primates (order)transcription factor SOX7/8/10/18 (SOX group E/F)
98F02Haplorrhini (suborder)transcription factor SOX7/8/10/18 (SOX group E/F)
BVA1VSimiiformes (infraorder)transcription factor SOX7/8/10/18 (SOX group E/F)
9EMBICatarrhini (parvorder)transcription factor SOX7/8/10/18 (SOX group E/F)
9FDKFVertebrata (clade)transcription factor SOX7/8/10/18 (SOX group E/F)
H522KBilateria (clade)transcription factor SOX17 (SOX group F),transcription factor SOX7/8/10/18 (SOX group E/F),transcription factor SOX1/3/14/21 (SOX group B)
7GZV8Opisthokonta (clade)transcription factor SOX1/3/14/21 (SOX group B),transcription factor SOX7/8/10/18 (SOX group E/F),transcription factor SOX11/12 (SOX group C)
FX2CQHominoidea (superfamily)transcription factor SOX7/8/10/18 (SOX group E/F)
5NE0AHominidae (family)transcription factor SOX7/8/10/18 (SOX group E/F)
5XW6SHomininae (subfamily)transcription factor SOX7/8/10/18 (SOX group E/F)

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: