Domains within Homo sapiens protein ACTT3_HUMAN (Q9BYD9)

Actin-related protein T3

Alternative representations: 1 /

Protein length372 aa
Source databaseUniProt
Identifiers ACTT3_HUMAN, Q9BYD9, ENSP00000333037.1, ENSP00000333037, Q96IS0, Q96NJ0
Source gene ENSG00000184378

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

ACTT3_HUMAN is shown as ACTRT3 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for ACTRT3

Protein ACTT3_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05132Salmonella infection
map04260Cardiac muscle contraction
map05014Amyotrophic lateral sclerosis

KEGG orthologous groups

KONameDescription
K10354ACTA1actin, alpha skeletal muscle
K12314ACTC1actin, alpha cardiac muscle
K10355ACTFactin, other eukaryote
K16575ACTR1, ARP1centractin

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000333037 in eggNOG.

OGTaxonomic classDescription
LCOG5277All organisms (root)actin, other eukaryote,actin-related protein 3,actin-related protein 2
KOG0676Eukaryota (superkingdom)actin, other eukaryote,centractin,reversibly glycosylated polypeptide / UDP-arabinopyranose mutase [EC:2.4.1.- 5.4.99.30]
HW0TBMetazoa (kingdom)centractin,actin, alpha skeletal muscle,actin, alpha cardiac muscle
94TU5Chordata (phylum)actin, alpha skeletal muscle,actin, alpha cardiac muscle
5RC9GSarcopterygii (superclass)actin, alpha skeletal muscle,actin, alpha cardiac muscle
8Z75YMammalia (class)Actin
4R1ZHEuarchontoglires (superorder)Actin
4ZUFJPrimates (order)Actin
98N5DHaplorrhini (suborder)Actin
BVI0ASimiiformes (infraorder)Actin
9EP8WCatarrhini (parvorder)Actin
7KX3WOpisthokonta (clade)centractin,actin, alpha cardiac muscle,actin beta/gamma 1
H48C2Bilateria (clade)actin, alpha skeletal muscle,actin, alpha cardiac muscle
9GC0YVertebrata (clade)actin, alpha skeletal muscle,actin, alpha cardiac muscle
FX39UHominoidea (superfamily)Actin
5N67ZHominidae (family)Actin
5Y200Homininae (subfamily)Actin

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: