Domains within Homo sapiens protein BARH1_HUMAN (Q9BZE3)

BarH-like 1 homeobox protein

Alternative representations: 1 /

Protein length327 aa
Source databaseUniProt
Identifiers BARH1_HUMAN, Q9BZE3, ENSP00000263610.2, ENSP00000263610, ENSP00000444704.1, ENSP00000444704, Q5T6V2, Q9NY88, H2QY32_PANTR, H2QY32, G3QZ20_GORGO, G3QZ20
Source gene ENSG00000125492

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

BARH1_HUMAN is shown as BARHL1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for BARHL1

Protein BARH1_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05202Transcriptional misregulation in cancer

KEGG orthologous groups

KONameDescription
K09360BARHLBarH-like

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 18 PTMs annotated in this protein:

PTMCount
Phosphorylation12
Acetylation6

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein BARHL1.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000263610 in eggNOG.

OGTaxonomic classDescription
LKOG0488All organisms (root)BarH-like,homeobox protein DBX,BarH-like homeobox
KOG0488Eukaryota (superkingdom)BarH-like,homeobox protein DBX,BarH-like homeobox
HTW1HMetazoa (kingdom)BarH-like,homeobox protein Nkx-5
94AWGChordata (phylum)BarH-like
5QRNZSarcopterygii (superclass)BarH-like
8ZMX9Mammalia (class)BarH-like
4RCEDEuarchontoglires (superorder)BarH-like
4ZJFRPrimates (order)BarH-like
986QAHaplorrhini (suborder)BarH-like
BV0KASimiiformes (infraorder)BarH-like
9EQPXCatarrhini (parvorder)BarH-like
9GKZIVertebrata (clade)BarH-like
H59CYBilateria (clade)BarH-like
7MMSZOpisthokonta (clade)BarH-like,homeobox protein Nkx-5
FX9DZHominoidea (superfamily)BarH-like
5NC84Hominidae (family)BarH-like
5Y2WTHomininae (subfamily)BarH-like

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: