Domains within Homo sapiens protein TANC1_HUMAN (Q9C0D5)

Protein TANC1

Alternative representations: 1 /

Protein length1861 aa
Source databaseUniProt
Identifiers TANC1_HUMAN, Q9C0D5, ENSP00000263635.6, ENSP00000263635, C9JD88, Q49AI8
Source gene ENSG00000115183

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

TANC1_HUMAN is shown as TANC1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for TANC1

Protein TANC1_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map03018RNA degradation
map04722Neurotrophin signaling pathway
map05166Human T-cell leukemia virus 1 infection

KEGG orthologous groups

KONameDescription
K10999CESAcellulose synthase A [EC:2.4.1.12]
K21440ANKRD50ankyrin repeat domain-containing protein 50
K06867K06867uncharacterized protein
K06499CEACAM, CD66carcinoembryonic antigen-related cell adhesion molecule

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 50 PTMs annotated in this protein:

PTMCount
Phosphorylation47
Acetylation2
Methylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein TANC1.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000263635 in eggNOG.

OGTaxonomic classDescription
LCOG0666All organisms (root)uncharacterized protein,Mce-associated membrane protein,cellulose synthase A [EC:2.4.1.12]
KOG0504Eukaryota (superkingdom)cellulose synthase A [EC:2.4.1.12],beta-mannan synthase [EC:2.4.1.32],uncharacterized protein
HVG4IMetazoa (kingdom)ankyrin repeat domain-containing protein 50,serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A,serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
93DEAChordata (phylum)Ank_2,Ank_4,TPR_8
5RDXCSarcopterygii (superclass)Ank_2,Ank,Ank_4
8ZCH6Mammalia (class)Ank_2,Ank,Ank_4
4R3ZNEuarchontoglires (superorder)Ank_2,Ank_4,Ank
4ZMTVPrimates (order)Ank_2,Ank_4,Ank
98EZCHaplorrhini (suborder)Ank_2,Ank_4,Ank
BV97YSimiiformes (infraorder)Ank_2,Ank
9EGVICatarrhini (parvorder)Ank_2,Ank
H4790Bilateria (clade)Ank_2,Ank_4,TPR_8
7MMYUOpisthokonta (clade)carcinoembryonic antigen-related cell adhesion molecule,ankyrin repeat domain-containing protein 50,NF-kappa-B inhibitor alpha
9GIUBVertebrata (clade)Ank_2,Ank,Ank_4
FX4MTHominoidea (superfamily)Ank_2,Ank
5N7TXHominidae (family)Ank_2,Ank
5Y6T3Homininae (subfamily)Ank_2,Ank

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: