Domains within Mus musculus protein LST8_MOUSE (Q9DCJ1)

Target of rapamycin complex subunit LST8

Alternative representations: 1 /

Protein length326 aa
Source databaseUniProt
Identifiers LST8_MOUSE, Q9DCJ1, ENSMUSP00000065004.6, ENSMUSP00000065004, ENSMUSP00000136287.1, ENSMUSP00000136287, Q8BNG8, Q8C882, Q9JKK6
Source gene ENSMUSG00000024142

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

LST8_MOUSE is shown as Mlst8 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Mlst8

Protein LST8_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04714Thermogenesis

KEGG orthologous groups

KONameDescription
K08266MLST8, GBLtarget of rapamycin complex subunit LST8

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 5 PTMs annotated in this protein:

PTMCount
Phosphorylation4
Ubiquitination1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Mlst8.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000157137 in eggNOG.

OGTaxonomic classDescription
LKOG0315All organisms (root)target of rapamycin complex subunit LST8,methyltransferase [EC:2.1.1.-],meiosis-specific with OB domain-containing protein [EC:3.1.-.-]
KOG0315Eukaryota (superkingdom)target of rapamycin complex subunit LST8,methyltransferase [EC:2.1.1.-],meiosis-specific with OB domain-containing protein [EC:3.1.-.-]
HVV87Metazoa (kingdom)target of rapamycin complex subunit LST8,meiosis-specific with OB domain-containing protein [EC:3.1.-.-]
93W5EChordata (phylum)target of rapamycin complex subunit LST8,meiosis-specific with OB domain-containing protein [EC:3.1.-.-]
5R07HSarcopterygii (superclass)target of rapamycin complex subunit LST8
8Z2M0Mammalia (class)target of rapamycin complex subunit LST8
4R76JEuarchontoglires (superorder)target of rapamycin complex subunit LST8
AHZM0Rodentia (order)target of rapamycin complex subunit LST8
8DIH1Myomorpha (suborder)target of rapamycin complex subunit LST8
7N11VOpisthokonta (clade)target of rapamycin complex subunit LST8,meiosis-specific with OB domain-containing protein [EC:3.1.-.-]
9G2JBVertebrata (clade)target of rapamycin complex subunit LST8,meiosis-specific with OB domain-containing protein [EC:3.1.-.-]
H5Q5TBilateria (clade)target of rapamycin complex subunit LST8,meiosis-specific with OB domain-containing protein [EC:3.1.-.-]
CQ7CYMuridae (family)target of rapamycin complex subunit LST8
AE9T1Murinae (subfamily)target of rapamycin complex subunit LST8
5PIXHMus (genus)target of rapamycin complex subunit LST8
HE3JTMus (subgenus)target of rapamycin complex subunit LST8

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: