Domains within Mus musculus protein TLR9_MOUSE (Q9EQU3)

Toll-like receptor 9

Alternative representations: 1 /

Protein length1032 aa
Source databaseUniProt
Identifiers TLR9_MOUSE, Q9EQU3, ENSMUSP00000082207.6, ENSMUSP00000082207, F8VPN5, Q4L0K3, Q4L0K4, Q99MF2, Q99MQ8
Source gene ENSMUSG00000045322

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

TLR9_MOUSE is shown as Tlr9 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Tlr9

Protein TLR9_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05162Measles
map05132Salmonella infection
map04620Toll-like receptor signaling pathway
map04514Cell adhesion molecules

KEGG orthologous groups

KONameDescription
K22038LRRC8volume-regulated anion channel
K10161TLR9, CD289toll-like receptor 9
K10159TLR2, CD282toll-like receptor 2

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000082207 in eggNOG.

OGTaxonomic classDescription
LCOG1552All organisms (root)volume-regulated anion channel,leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein,protein phosphatase 1 regulatory subunit 7
KOG4641Eukaryota (superkingdom)toll-like receptor 2,toll-like receptor 3,toll-like receptor 7
HV078Metazoa (kingdom)toll-like receptor 9,toll-like receptor 7,twinfilin
94QGBChordata (phylum)toll-like receptor 9,toll-like receptor 7,twinfilin
5QVMGSarcopterygii (superclass)toll-like receptor 9,toll-like receptor 7,twinfilin
8YW76Mammalia (class)toll-like receptor 9,twinfilin
4R4W9Euarchontoglires (superorder)toll-like receptor 9,twinfilin
AI4FURodentia (order)toll-like receptor 9,twinfilin
8D7D6Myomorpha (suborder)toll-like receptor 9,twinfilin
7MP92Opisthokonta (clade)toll-like receptor 9,toll-like receptor 7,twinfilin
9FJPBVertebrata (clade)toll-like receptor 9,toll-like receptor 7,twinfilin
H4EM3Bilateria (clade)toll-like receptor 9,toll-like receptor 7,twinfilin
CQ8B0Muridae (family)toll-like receptor 9
AE305Murinae (subfamily)toll-like receptor 9
5PM9KMus (genus)toll-like receptor 9
HE2C5Mus (subgenus)toll-like receptor 9

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: