Domains within Homo sapiens protein GSX1_HUMAN (Q9H4S2)

GS homeobox 1

Alternative representations: 1 /

Protein length264 aa
Source databaseUniProt
Identifiers GSX1_HUMAN, Q9H4S2, ENSP00000304331.2, ENSP00000304331, Q9UD62, H2Q7C3_PANTR, H2Q7C3, G3QQN4_GORGO, G3QQN4
Source gene ENSG00000169840

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

GSX1_HUMAN is shown as GSX1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for GSX1

Protein GSX1_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04550Signaling pathways regulating pluripotency of stem cells

KEGG orthologous groups

KONameDescription
K09304HOX_4homeobox protein HoxA/B/C/D4

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 6 PTMs annotated in this protein:

PTMCount
Phosphorylation6

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein ENSPTRG00000005735.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000304331 in eggNOG.

OGTaxonomic classDescription
LKOG0489All organisms (root)homeobox protein HoxA/B/C/D4,homeobox protein HoxA/B/C5,homeobox protein HoxA/B/D3
KOG0489Eukaryota (superkingdom)homeobox protein HoxA/B/C/D4,homeobox protein HoxA/B/C5,homeobox protein HoxA/B/D3
HUF8EMetazoa (kingdom)homeobox protein GSH
93QT4Chordata (phylum)homeobox protein GSH
5QWVHSarcopterygii (superclass)homeobox protein GSH
8ZCMTMammalia (class)homeobox protein GSH
4RCGHEuarchontoglires (superorder)homeobox protein GSH
4ZVXRPrimates (order)homeobox protein GSH
98RA5Haplorrhini (suborder)homeobox protein GSH
BVB9JSimiiformes (infraorder)homeobox protein GSH
9EN0TCatarrhini (parvorder)homeobox protein GSH
9FQUAVertebrata (clade)homeobox protein GSH
H51GSBilateria (clade)homeobox protein GSH
7NPVYOpisthokonta (clade)homeobox protein GSH,homeobox protein HoxA/B/C6
FX251Hominoidea (superfamily)homeobox protein GSH
5NE1XHominidae (family)homeobox protein GSH
5Y4HVHomininae (subfamily)homeobox protein GSH

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: