Domains within Homo sapiens protein SYF1_HUMAN (Q9HCS7)

Pre-mRNA-splicing factor SYF1

Alternative representations: 1 /

Protein length855 aa
Source databaseUniProt
Identifiers SYF1_HUMAN, Q9HCS7, ENSP00000351137.3, ENSP00000351137, Q8TET6, Q96HB0, Q96IW0, Q9NRG6, Q9ULP3, K7BVP4_PANTR, K7BVP4, H2QZR1, Q68CN2_HUMAN, Q68CN2
Source gene ENSG00000076924

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

SYF1_HUMAN is shown as XAB2 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for XAB2

Protein SYF1_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map03040Spliceosome

KEGG orthologous groups

KONameDescription
K12867SYF1, XAB2pre-mRNA-splicing factor SYF1

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 17 PTMs annotated in this protein:

PTMCount
Ubiquitination12
Phosphorylation4
Acetylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein DKFZp762C1015.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000351137 in eggNOG.

OGTaxonomic classDescription
LKOG2047All organisms (root)pre-mRNA-splicing factor SYF1
KOG2047Eukaryota (superkingdom)pre-mRNA-splicing factor SYF1
HW3DPMetazoa (kingdom)pre-mRNA-splicing factor SYF1
94U7EChordata (phylum)pre-mRNA-splicing factor SYF1
5R7XUSarcopterygii (superclass)pre-mRNA-splicing factor SYF1
8ZMVUMammalia (class)pre-mRNA-splicing factor SYF1
4RE8DEuarchontoglires (superorder)pre-mRNA-splicing factor SYF1
502B0Primates (order)pre-mRNA-splicing factor SYF1
98CQ5Haplorrhini (suborder)pre-mRNA-splicing factor SYF1
BV26KSimiiformes (infraorder)pre-mRNA-splicing factor SYF1
9F1MFCatarrhini (parvorder)pre-mRNA-splicing factor SYF1
9GJ4BVertebrata (clade)pre-mRNA-splicing factor SYF1
7NSK9Opisthokonta (clade)pre-mRNA-splicing factor SYF1
H700SBilateria (clade)pre-mRNA-splicing factor SYF1
FXBBQHominoidea (superfamily)pre-mRNA-splicing factor SYF1
5N6TDHominidae (family)pre-mRNA-splicing factor SYF1
5Y8YXHomininae (subfamily)pre-mRNA-splicing factor SYF1

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: