Domains within Danio rerio protein Q9I9E8_DANRE (Q9I9E8)

E4tf1-60 transcription factor

Alternative representations: 1 /

Protein length455 aa
Source databaseUniProt
Identifiers Q9I9E8_DANRE, Q9I9E8, ENSDARP00000150776.1, ENSDARP00000150776, ENSDARP00000154460.1, ENSDARP00000154460, ENSDARP00000091474.3, ENSDARP00000091474, ENSDARP00000091473.4, ENSDARP00000091473
Source gene ENSDARG00000069289
Alternative splicing Q9I9E8_DANRE, ENSDARP00000118644.1

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Bilateria

Predicted functional partners

Q9I9E8_DANRE is shown as gabpa in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for gabpa

Protein Q9I9E8_DANRE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05202Transcriptional misregulation in cancer
map04514Cell adhesion molecules

KEGG orthologous groups

KONameDescription
K09441GABPAGA-binding protein transcription factor, alpha
K09436FLI1friend leukemia integration 1 transcription factor

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7955.ENSDARP00000091474 in eggNOG.

OGTaxonomic classDescription
LKOG3806All organisms (root)friend leukemia integration 1 transcription factor,C-ets-1,GA-binding protein transcription factor, alpha
9IGKQOtomorpha (cohort)GA-binding protein transcription factor, alpha
KOG3806Eukaryota (superkingdom)friend leukemia integration 1 transcription factor,C-ets-1,GA-binding protein transcription factor, alpha
HVFSGMetazoa (kingdom)GA-binding protein transcription factor, alpha,junctional adhesion molecule 2
93PDRChordata (phylum)GA-binding protein transcription factor, alpha,junctional adhesion molecule 2
FXXPZActinopterygii (superclass)GA-binding protein transcription factor, alpha
8NF32Neopterygii (subclass)GA-binding protein transcription factor, alpha
H6QZMBilateria (clade)GA-binding protein transcription factor, alpha,junctional adhesion molecule 2
9FAD8Vertebrata (clade)GA-binding protein transcription factor, alpha,junctional adhesion molecule 2
7KP18Opisthokonta (clade)GA-binding protein transcription factor, alpha,junctional adhesion molecule 2
BEZ3GCyprinidae (family)GA-binding protein transcription factor, alpha

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: