Domains within Mus musculus protein HERP1_MOUSE (Q9JJK5)

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

Alternative representations: 1 /

Protein length391 aa
Source databaseUniProt
Identifiers HERP1_MOUSE, Q9JJK5, ENSMUSP00000124201.1, ENSMUSP00000124201, Q6A0E4_MOUSE, Q6A0E4, Q3TMN9_MOUSE, Q3TMN9, A0A0P4WWT8_9CRUS, A0A0P4WWT8
Source gene ENSMUSG00000031770
Alternative splicing HERP1_MOUSE, Q8C4N0_MOUSE, A0A1D5RLM1_MOUSE, A0A1D5RMG9_MOUSE, A0A1D5RM09_MOUSE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

HERP1_MOUSE is shown as Herpud1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Herpud1

Protein HERP1_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04141Protein processing in endoplasmic reticulum

KEGG orthologous groups

KONameDescription
K14027HERPUD1, HERPhomocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 3 PTMs annotated in this protein:

PTMCount
Phosphorylation3

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Herpud1.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000124201 in eggNOG.

OGTaxonomic classDescription
LKOG4583All organisms (root)homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
KOG4583Eukaryota (superkingdom)homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
HVUY4Metazoa (kingdom)homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
94PWGChordata (phylum)homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
5QFJZSarcopterygii (superclass)homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
8Z50WMammalia (class)homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
4R6VPEuarchontoglires (superorder)homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
AI2NQRodentia (order)homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
8DDX8Myomorpha (suborder)homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
9GJATVertebrata (clade)homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
7I9DCOpisthokonta (clade)homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
H5TH0Bilateria (clade)homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
CQ3B8Muridae (family)homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
AE3AJMurinae (subfamily)homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
5PGUFMus (genus)homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
HE63WMus (subgenus)homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: