Domains within Mus musculus protein TRFM_MOUSE (Q9R0R1)

Melanotransferrin

Alternative representations: 1 /

Protein length738 aa
Source databaseUniProt
Identifiers TRFM_MOUSE, Q9R0R1, ENSMUSP00000023464.5, ENSMUSP00000023464, Q544J8_MOUSE, Q544J8
Source gene ENSMUSG00000022780

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Coelomata

Predicted functional partners

TRFM_MOUSE is shown as Meltf in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Meltf

Protein TRFM_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04216Ferroptosis
map04514Cell adhesion molecules

KEGG orthologous groups

KONameDescription
K07378NLGNneuroligin
K03929pnbApara-nitrobenzyl esterase [EC:3.1.1.-]
K14736TFtransferrin
K06569MFI2, CD228melanoma-associated antigen p97

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 14 PTMs annotated in this protein:

PTMCount
Phosphorylation11
Acetylation3

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Mfi2.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000023464 in eggNOG.

OGTaxonomic classDescription
LCOG2272All organisms (root)para-nitrobenzyl esterase [EC:3.1.1.-],neuroligin,acetylcholinesterase [EC:3.1.1.7]
KOG1516Eukaryota (superkingdom)neuroligin,carboxylesterase 2 [EC:3.1.1.1 3.1.1.84 3.1.1.56],protein APCDD1
HSYBDMetazoa (kingdom)melanoma-associated antigen p97,transferrin,lactotransferrin [EC:3.4.21.-]
94PIYChordata (phylum)transferrin,melanoma-associated antigen p97,lactotransferrin [EC:3.4.21.-]
5QJAASarcopterygii (superclass)transferrin,melanoma-associated antigen p97,lactotransferrin [EC:3.4.21.-]
8ZIA6Mammalia (class)melanoma-associated antigen p97
4R6JAEuarchontoglires (superorder)melanoma-associated antigen p97
AI3R7Rodentia (order)melanoma-associated antigen p97
8D6TVMyomorpha (suborder)melanoma-associated antigen p97
9FDYBVertebrata (clade)transferrin,melanoma-associated antigen p97,lactotransferrin [EC:3.4.21.-]
H6U2PBilateria (clade)melanoma-associated antigen p97,transferrin,lactotransferrin [EC:3.4.21.-]
7H6N7Opisthokonta (clade)melanoma-associated antigen p97,transferrin,lactotransferrin [EC:3.4.21.-]
CQ3WAMuridae (family)melanoma-associated antigen p97
AE15YMurinae (subfamily)melanoma-associated antigen p97
5PVWPMus (genus)melanoma-associated antigen p97
HEA5AMus (subgenus)melanoma-associated antigen p97

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: