Domains within Nomascus leucogenys protein G1R0B2_NOMLE (G1R0B2)

Uncharacterized protein

Alternative representations: 1 /

Protein length506 aa
Source databaseUniProt
Identifiers G1R0B2_NOMLE, G1R0B2, ENSNLEP00000006633.2, ENSNLEP00000006633, Q9UF30_HUMAN, Q9UF30, A0A2I3HIG6_NOMLE, A0A2I3HIG6
Source gene ENSNLEG00000005466
Alternative splicing ENSNLEP00000043256.1, G1R0B2_NOMLE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

G1R0B2_NOMLE is shown as VPS4A in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for VPS4A

Protein G1R0B2_NOMLE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04217Necroptosis

KEGG orthologous groups

KONameDescription
K12196VPS4vacuolar protein-sorting-associated protein 4

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 61853.ENSNLEP00000006633 in eggNOG.

OGTaxonomic classDescription
LKOG0739All organisms (root)vacuolar protein-sorting-associated protein 4,serine/threonine-protein kinase ULK3 [EC:2.7.11.1]
KOG0739Eukaryota (superkingdom)vacuolar protein-sorting-associated protein 4,serine/threonine-protein kinase ULK3 [EC:2.7.11.1]
HVBYVMetazoa (kingdom)vacuolar protein-sorting-associated protein 4
93E1AChordata (phylum)vacuolar protein-sorting-associated protein 4
5RAEASarcopterygii (superclass)vacuolar protein-sorting-associated protein 4
8ZDZMMammalia (class)vacuolar protein-sorting-associated protein 4
4RB3IEuarchontoglires (superorder)vacuolar protein-sorting-associated protein 4
4ZX2UPrimates (order)vacuolar protein-sorting-associated protein 4
98NIUHaplorrhini (suborder)vacuolar protein-sorting-associated protein 4
BV8UKSimiiformes (infraorder)vacuolar protein-sorting-associated protein 4
9EYPACatarrhini (parvorder)vacuolar protein-sorting-associated protein 4
H4ENPBilateria (clade)vacuolar protein-sorting-associated protein 4
7J5J9Opisthokonta (clade)vacuolar protein-sorting-associated protein 4,serine/threonine-protein kinase ULK3 [EC:2.7.11.1]
9FC8RVertebrata (clade)vacuolar protein-sorting-associated protein 4
FWY8RHominoidea (superfamily)vacuolar protein-sorting-associated protein 4

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: