Domains within Homo sapiens protein RGS17_HUMAN (Q9UGC6)

Regulator of G-protein signaling 17

Alternative representations: 1 /

Protein length210 aa
Source databaseUniProt
Identifiers RGS17_HUMAN, Q9UGC6, ENSP00000356194.1, ENSP00000356194, ENSP00000206262.1, ENSP00000206262, Q5TF49, Q8TD61, Q9UJS8, H9F198_MACMU, H9F198, H2R6V7_PANTR, H2R6V7, F7ISK0_CALJA, F7ISK0, F6QJW7_MACMU, F6QJW7, G7MQ33, G7P4X8_MACFA, G7P4X8, H2PKP0_PONAB, H2PKP0, G3RNN8_GORGO, G3RNN8, A0A2K6LK32_RHIBE, A0A2K6LK32, A0A2K6D5X6_MACNE, A0A2K6D5X6, A0A2K6Q4L8_RHIRO, A0A2K6Q4L8, A0A096NYS7_PAPAN, A0A096NYS7, A0A2K6RYS0_SAIBB, A0A2K6RYS0, G1RZT6_NOMLE, G1RZT6
Source gene ENSG00000091844

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

RGS17_HUMAN is shown as RGS17 in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for RGS17

Protein RGS17_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05225Hepatocellular carcinoma

KEGG orthologous groups

KONameDescription
K16449RGSregulator of G-protein signaling

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 4 PTMs annotated in this protein:

PTMCount
Phosphorylation4

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein ENSPTRG00000029367.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000206262 in eggNOG.

OGTaxonomic classDescription
LKOG3589All organisms (root)regulator of G-protein signaling,axin 1,regulator of G-protein signaling 2
KOG3589Eukaryota (superkingdom)regulator of G-protein signaling,axin 1,regulator of G-protein signaling 2
HUGXGMetazoa (kingdom)regulator of G-protein signaling
93VTXChordata (phylum)regulator of G-protein signaling
5QM8YSarcopterygii (superclass)regulator of G-protein signaling
8ZFF2Mammalia (class)regulator of G-protein signaling
4R93NEuarchontoglires (superorder)regulator of G-protein signaling
4ZQ8RPrimates (order)regulator of G-protein signaling
985T1Haplorrhini (suborder)regulator of G-protein signaling
BUYNWSimiiformes (infraorder)regulator of G-protein signaling
9EMRSCatarrhini (parvorder)regulator of G-protein signaling
9GUJ4Vertebrata (clade)regulator of G-protein signaling
7N24XOpisthokonta (clade)regulator of G-protein signaling
H6E3ZBilateria (clade)regulator of G-protein signaling
FX3VVHominoidea (superfamily)regulator of G-protein signaling
5N4H1Hominidae (family)regulator of G-protein signaling
5XYUWHomininae (subfamily)regulator of G-protein signaling

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: