Domains within Homo sapiens protein TES_HUMAN (Q9UGI8)

Testin

Alternative representations: 1 /

Protein length421 aa
Source databaseUniProt
Identifiers TES_HUMAN, Q9UGI8, ENSP00000350937.4, ENSP00000350937, A4D0U6, Q9GZQ1, Q9HAJ9, TES_PANTR, Q2QLF4, TES_PONAB, Q5RC52, Q2IBD5, Q5R5G7, A4D0U5_HUMAN, A4D0U5, K7CDU7_PANTR, K7CDU7, A0A2J8UPH8_PONAB, A0A2J8UPH8
Source gene ENSG00000135269
Alternative splicing TES_HUMAN, ENSP00000413002.1, F8WDI4_HUMAN, ENSP00000377121.2, H7BYK1_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

TES_HUMAN is shown as TES in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for TES

Protein TES_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04310Wnt signaling pathway

KEGG orthologous groups

KONameDescription
K04511PRICKLEprickle

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 29 PTMs annotated in this protein:

PTMCount
Phosphorylation16
Ubiquitination8
Acetylation4
Nitrosylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein DKFZp586B2022.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000350937 in eggNOG.

OGTaxonomic classDescription
LKOG1704All organisms (root)prickle,four and a half LIM domains protein 1,four and a half LIM domains protein 2
KOG1704Eukaryota (superkingdom)prickle,four and a half LIM domains protein 1,four and a half LIM domains protein 2
HTFMUMetazoa (kingdom)testin
94UBXChordata (phylum)testin
5QT2CSarcopterygii (superclass)testin
8Z5JXMammalia (class)testin
4R2VPEuarchontoglires (superorder)testin
4ZTC6Primates (order)testin
9885AHaplorrhini (suborder)testin
BV6BSSimiiformes (infraorder)testin
9EMCTCatarrhini (parvorder)testin
9FS02Vertebrata (clade)testin
7GHJ5Opisthokonta (clade)testin
H3IVJBilateria (clade)testin
FX2QXHominoidea (superfamily)testin
5N4AJHominidae (family)testin
5Y18SHomininae (subfamily)testin

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: