Domains within Homo sapiens protein VPRE3_HUMAN (Q9UKI3)

Pre-B lymphocyte protein 3

Alternative representations: 1 /

Protein length123 aa
Source databaseUniProt
Identifiers VPRE3_HUMAN, Q9UKI3, ENSP00000248948.3, ENSP00000248948, B2R587
Source gene ENSG00000128218
Alternative splicing A8MX21_HUMAN, VPRE3_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

VPRE3_HUMAN is shown as VPREB3 in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for VPREB3

Protein VPRE3_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05340Primary immunodeficiency
map05014Amyotrophic lateral sclerosis
map04514Cell adhesion molecules

KEGG orthologous groups

KONameDescription
K06553VPREB, CD179apre-B lymphocyte gene
K25874KIRREL, NEPHKirrel/Neph family protein

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000248948 in eggNOG.

OGTaxonomic classDescription
LKOG3510All organisms (root)Kirrel/Neph family protein,neural cell adhesion molecule,neurotrimin
KOG3510Eukaryota (superkingdom)Kirrel/Neph family protein,neural cell adhesion molecule,neurotrimin
HUQD5Metazoa (kingdom)pre-B lymphocyte gene,immunoglobulin lambda-like polypeptide 1,T cell receptor alpha chain V region
94SUQChordata (phylum)pre-B lymphocyte gene,coiled-coil-helix-coiled-coil-helix domain-containing protein 10
5R32QSarcopterygii (superclass)pre-B lymphocyte gene,coiled-coil-helix-coiled-coil-helix domain-containing protein 10
8ZBZ2Mammalia (class)pre-B lymphocyte gene
4RMI5Euarchontoglires (superorder)pre-B lymphocyte gene
500WQPrimates (order)pre-B lymphocyte gene
98EHCHaplorrhini (suborder)pre-B lymphocyte gene
BV98RSimiiformes (infraorder)pre-B lymphocyte gene
9EM52Catarrhini (parvorder)pre-B lymphocyte gene
H6AZCBilateria (clade)pre-B lymphocyte gene,coiled-coil-helix-coiled-coil-helix domain-containing protein 10
7ISQZOpisthokonta (clade)pre-B lymphocyte gene,immunoglobulin lambda-like polypeptide 1,T cell receptor alpha chain V region
9GF8KVertebrata (clade)pre-B lymphocyte gene,coiled-coil-helix-coiled-coil-helix domain-containing protein 10
FX6CCHominoidea (superfamily)pre-B lymphocyte gene
5N8X2Hominidae (family)pre-B lymphocyte gene
5Y919Homininae (subfamily)pre-B lymphocyte gene

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: