Domains within Drosophila melanogaster protein Q9VFN7_DROME (Q9VFN7)

GEO07678p1

Alternative representations: 1 /

Protein length159 aa
Source databaseUniProt
Identifiers Q9VFN7_DROME, Q9VFN7, FBPP0082350, FBPP0082349
Source gene FBgn0038198

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

Q9VFN7_DROME is shown as Npc2b in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Npc2b

Protein Q9VFN7_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04979Cholesterol metabolism

KEGG orthologous groups

KONameDescription
K13443NPC2Niemann-Pick C2 protein

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0082350 in eggNOG.

OGTaxonomic classDescription
EIYSIEndopterygota (cohort)Niemann-Pick C2 protein
LKOG4063All organisms (root)Niemann-Pick C2 protein,retinol-binding protein 4,mitotic-spindle organizing protein 2A/2B
FDYBQmelanogaster subgroup (species subgroup)Niemann-Pick C2 protein
FUXDFmelanogaster group (species group)Niemann-Pick C2 protein
KOG4063Eukaryota (superkingdom)Niemann-Pick C2 protein,retinol-binding protein 4,mitotic-spindle organizing protein 2A/2B
HVD9IMetazoa (kingdom)Niemann-Pick C2 protein,retinol-binding protein 4
HIG64Arthropoda (phylum)Niemann-Pick C2 protein
8699AHexapoda (subphylum)Niemann-Pick C2 protein
AH1A3Neoptera (infraclass)Niemann-Pick C2 protein
AP004Diptera (order)Niemann-Pick C2 protein
H4DMFBilateria (clade)Niemann-Pick C2 protein,retinol-binding protein 4
7K0X2Opisthokonta (clade)Niemann-Pick C2 protein,retinol-binding protein 4,mitotic-spindle organizing protein 2A/2B
EH6VKDrosophila (genus)Niemann-Pick C2 protein
50KVHSophophora (subgenus)Niemann-Pick C2 protein

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: