Domains within Drosophila melanogaster protein TGO1_DROME (Q9VMA7)

Transport and Golgi organization protein 1

Alternative representations: 1 /

Protein length1430 aa
Source databaseUniProt
Identifiers TGO1_DROME, Q9VMA7, FBPP0292316, FBPP0078925, Q8SY42, Q9VMA8
Source gene FBgn0031842
Alternative splicing X2J786_DROME, TGO1_DROME

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

TGO1_DROME is shown as Tango1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Tango1

Protein TGO1_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05165Human papillomavirus infection

KEGG orthologous groups

KONameDescription
K00430E1.11.1.7peroxidase [EC:1.11.1.7] iPath3
K04659THBS2Sthrombospondin 2/3/4/5
Some of these orthologous groups are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 20 PTMs annotated in this protein:

PTMCount
Phosphorylation12
N-linked glycosylation6
Ubiquitination2

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Tango1.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0078925 in eggNOG.

OGTaxonomic classDescription
7553HAll organisms (root)peroxidase [EC:1.11.1.7],transmembrane channel-like protein,thrombospondin 2/3/4/5
EIGNCEndopterygota (cohort)transport and golgi organization protein 1
KOG1217Eukaryota (superkingdom)peroxidase [EC:1.11.1.7],transmembrane channel-like protein,thrombospondin 2/3/4/5
HSY91Metazoa (kingdom)thrombospondin 2/3/4/5,delta,matrilin
HITJCArthropoda (phylum)transport and golgi organization protein 1
85KGZHexapoda (subphylum)transport and golgi organization protein 1
AGJ7YNeoptera (infraclass)transport and golgi organization protein 1
ANSYGDiptera (order)transport and golgi organization protein 1
7NXWDOpisthokonta (clade)thrombospondin 2/3/4/5,delta,matrilin
H5MPZBilateria (clade)transport and golgi organization protein 1,spermatogenic leucine zipper protein 1,melanoma inhibitory activity protein 2

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: