Domains within Drosophila melanogaster protein Q9VMY8_DROME (Q9VMY8)
Auxilin, isoform A
Alternative representations: 1 /
| Protein length | 1165 aa |
|---|---|
| Source database | UniProt |
| Identifiers | Q9VMY8_DROME, Q9VMY8, FBPP0078605, FBPP0078604, Q8T0A7_DROME, Q8T0A7 |
| Source gene | FBgn0037218 |
| Alternative splicing | A0A0B4KG14_DROME, A0A0B4KF57_DROME, Q9VMY8_DROME |
Domain architecture analysis
Display all proteins with similar:
| Domain organisation | Proteins having all the domains as the query in the same order. Additional domains are allowed. |
|---|---|
| Domain composition | Proteins with the same domain composition have at least one copy of each of the domains of the query. |
Predicted functional partners
Q9VMY8_DROME is shown as 
aux in the network
Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.
The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.
Protein Q9VMY8_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:
KEGG pathways
| Pathway | Description | |
|---|---|---|
| map04010 | MAPK signaling pathway | |
| map00514 | Other types of O-glycan biosynthesis | iPath3 |
| map05202 | Transcriptional misregulation in cancer | |
| map04144 | Endocytosis |
KEGG orthologous groups
| KO | Name | Description | |
|---|---|---|---|
| K14165 | K14165 | atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48] | |
| K01110 | PTEN | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67] | |
| K08855 | GAK | cyclin G-associated kinase [EC:2.7.11.1] | |
| K08853 | AAK | AP2-associated kinase [EC:2.7.11.1] | |
| K20783 | RRA | arabinosyltransferase [EC:2.4.2.-] |
Post-translational modifications
PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 31 PTMs annotated in this protein:
| PTM | Count | |
|---|---|---|
 | Phosphorylation | 22 |
 | Ubiquitination | 6 |
 | Acetylation | 2 |
 | Methylation | 1 |
To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein aux.
Orthologous groups
Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0078604 in eggNOG.
| OG | Taxonomic class | Description |
|---|---|---|
| LKOG0431 | All organisms (root) | arabinosyltransferase [EC:2.4.2.-],cyclin G-associated kinase [EC:2.7.11.1],DnaJ homolog subfamily C member 6 |
| EIFW7 | Endopterygota (cohort) | cyclin G-associated kinase [EC:2.7.11.1] |
| LCOG2453 | All organisms (root) | atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48],dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48],dual specificity phosphatase 12 [EC:3.1.3.16 3.1.3.48] |
| FDZH8 | melanogaster subgroup (species subgroup) | cyclin G-associated kinase [EC:2.7.11.1] |
| FUZ2X | melanogaster group (species group) | cyclin G-associated kinase [EC:2.7.11.1] |
| LKOG1989 | All organisms (root) | AP2-associated kinase [EC:2.7.11.1],cyclin G-associated kinase [EC:2.7.11.1],BMP2 inducible kinase [EC:2.7.11.1] |
| KOG2283 | Eukaryota (superkingdom) | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67],tensin,cyclin G-associated kinase [EC:2.7.11.1] |
| KOG1989 | Eukaryota (superkingdom) | AP2-associated kinase [EC:2.7.11.1],cyclin G-associated kinase [EC:2.7.11.1],BMP2 inducible kinase [EC:2.7.11.1] |
| KOG0431 | Eukaryota (superkingdom) | arabinosyltransferase [EC:2.4.2.-],cyclin G-associated kinase [EC:2.7.11.1],DnaJ homolog subfamily C member 6 |
| HUYV1 | Metazoa (kingdom) | cyclin G-associated kinase [EC:2.7.11.1],DnaJ homolog subfamily C member 6,AP2-associated kinase [EC:2.7.11.1] |
| HIYER | Arthropoda (phylum) | cyclin G-associated kinase [EC:2.7.11.1] |
| 85WD0 | Hexapoda (subphylum) | cyclin G-associated kinase [EC:2.7.11.1] |
| AHM9B | Neoptera (infraclass) | cyclin G-associated kinase [EC:2.7.11.1] |
| ANECU | Diptera (order) | cyclin G-associated kinase [EC:2.7.11.1] |
| H5K7U | Bilateria (clade) | cyclin G-associated kinase [EC:2.7.11.1],DnaJ homolog subfamily C member 6,AP2-associated kinase [EC:2.7.11.1] |
| 7NKI3 | Opisthokonta (clade) | cyclin G-associated kinase [EC:2.7.11.1],DnaJ homolog subfamily C member 6,protein fem-1 homolog A/C |
| EH2CJ | Drosophila (genus) | cyclin G-associated kinase [EC:2.7.11.1] |
| 50K56 | Sophophora (subgenus) | cyclin G-associated kinase [EC:2.7.11.1] |
The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.