Domains within Drosophila melanogaster protein KP58_DROME (Q9VPC0)

Serine/threonine-protein kinase PITSLRE

Alternative representations: 1 /

Protein length952 aa
Source databaseUniProt
Identifiers KP58_DROME, Q9VPC0, FBPP0077905, FBPP0077908, Q5U100, Q8MQR7, Q94889, Q9TXB3, D3PFF6_DROME, D3PFF6
Source gene FBgn0016696
Alternative splicing KP58_DROME, FBpp0293474

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

KP58_DROME is shown as Pitslre in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Pitslre

Protein KP58_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04111Cell cycle - yeast

KEGG orthologous groups

KONameDescription
K08818CDC2Lcell division cycle 2-like [EC:2.7.11.22]

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 26 PTMs annotated in this protein:

PTMCount
Phosphorylation23
Ubiquitination2
Acetylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Pitslre.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0077905 in eggNOG.

OGTaxonomic classDescription
EIZNPEndopterygota (cohort)cell division cycle 2-like [EC:2.7.11.22]
FE0RJmelanogaster subgroup (species subgroup)cell division cycle 2-like [EC:2.7.11.22]
FUZ08melanogaster group (species group)cell division cycle 2-like [EC:2.7.11.22]
LKOG0663All organisms (root)cell division cycle 2-like [EC:2.7.11.22],cyclin-dependent kinase 10 [EC:2.7.11.22],hydrolethalus syndrome protein 1
KOG0663Eukaryota (superkingdom)cell division cycle 2-like [EC:2.7.11.22],cyclin-dependent kinase 10 [EC:2.7.11.22],hydrolethalus syndrome protein 1
HU7HUMetazoa (kingdom)cyclin-dependent kinase 10 [EC:2.7.11.22],cell division cycle 2-like [EC:2.7.11.22],solute carrier family 35, member E2
HIW8VArthropoda (phylum)cell division cycle 2-like [EC:2.7.11.22]
86GH3Hexapoda (subphylum)cell division cycle 2-like [EC:2.7.11.22]
AHJ9FNeoptera (infraclass)cell division cycle 2-like [EC:2.7.11.22]
ANKIADiptera (order)cell division cycle 2-like [EC:2.7.11.22]
H6J42Bilateria (clade)cyclin-dependent kinase 10 [EC:2.7.11.22],cell division cycle 2-like [EC:2.7.11.22],solute carrier family 35, member E2
7HBYUOpisthokonta (clade)cyclin-dependent kinase 10 [EC:2.7.11.22],cell division cycle 2-like [EC:2.7.11.22],solute carrier family 35, member E2
EGZAIDrosophila (genus)cell division cycle 2-like [EC:2.7.11.22]
50HMUSophophora (subgenus)cell division cycle 2-like [EC:2.7.11.22]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: