Domains within Drosophila melanogaster protein Q8WS79_DROME (Q8WS79)

Estrogen-related receptor splice variant

Alternative representations: 1 /

Protein length496 aa
Source databaseUniProt
Identifiers Q8WS79_DROME, Q8WS79, FBPP0076448, Q9VSE9_DROME, Q9VSE9
Source gene FBgn0035849
Alternative splicing FBpp0076447, Q8WS79_DROME

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Metazoa

Predicted functional partners

Q8WS79_DROME is shown as ERR in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for ERR

Protein Q8WS79_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04550Signaling pathways regulating pluripotency of stem cells
map05200Pathways in cancer

KEGG orthologous groups

KONameDescription
K08554NR3B3, ESRRGestrogen-related receptor gamma

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 2 PTMs annotated in this protein:

PTMCount
Phosphorylation1
Ubiquitination1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein ERR.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0076448 in eggNOG.

OGTaxonomic classDescription
FV4ZJmelanogaster group (species group)estrogen-related receptor ERR
LKOG3575All organisms (root)estrogen-related receptor gamma,nuclear receptor subfamily 2 group E member 3,retinoid X receptor alpha
FDZZGmelanogaster subgroup (species subgroup)estrogen-related receptor ERR
EIZJDEndopterygota (cohort)estrogen-related receptor ERR
KOG3575Eukaryota (superkingdom)estrogen-related receptor gamma,nuclear receptor subfamily 2 group E member 3,retinoid X receptor alpha
HVHX2Metazoa (kingdom)estrogen-related receptor gamma,estrogen-related receptor beta,estrogen-related receptor alpha
HI9KZArthropoda (phylum)estrogen-related receptor ERR
85F4YHexapoda (subphylum)estrogen-related receptor ERR
AHR85Neoptera (infraclass)estrogen-related receptor ERR
ANBWIDiptera (order)estrogen-related receptor ERR
7JYUPOpisthokonta (clade)estrogen-related receptor gamma,estrogen-related receptor beta,estrogen-related receptor alpha
H3HJYBilateria (clade)estrogen-related receptor gamma,estrogen-related receptor beta,estrogen-related receptor alpha
EGXEMDrosophila (genus)estrogen-related receptor ERR
50P1YSophophora (subgenus)estrogen-related receptor ERR

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: