Domains within Drosophila melanogaster protein Q9W3I9_DROME (Q9W3I9)

GH01161p

Alternative representations: 1 /

Protein length475 aa
Source databaseUniProt
Identifiers Q9W3I9_DROME, Q9W3I9, FBPP0071136, B4R6G7_DROSI, B4R6G7
Source gene FBgn0265464

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

Q9W3I9_DROME is shown as Traf6 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Traf6

Protein Q9W3I9_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04657IL-17 signaling pathway
map04936Alcoholic liver disease
map05200Pathways in cancer

KEGG orthologous groups

KONameDescription
K03175TRAF6TNF receptor-associated factor 6 [EC:2.3.2.27]
K09848TRAF4TNF receptor-associated factor 4

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 1 PTMs annotated in this protein:

PTMCount
SUMOylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Traf6.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0071136 in eggNOG.

OGTaxonomic classDescription
EJ5ANEndopterygota (cohort)TNF receptor-associated factor 6 [EC:2.3.2.27]
LKOG0297All organisms (root)TNF receptor-associated factor 4,ligand of Numb protein X 3/4 [EC:2.3.2.27],TNF receptor-associated factor 2 [EC:2.3.2.27]
FV1W5melanogaster group (species group)TNF receptor-associated factor 6 [EC:2.3.2.27]
FE3QGmelanogaster subgroup (species subgroup)TNF receptor-associated factor 6 [EC:2.3.2.27]
KOG0297Eukaryota (superkingdom)TNF receptor-associated factor 4,ligand of Numb protein X 3/4 [EC:2.3.2.27],TNF receptor-associated factor 2 [EC:2.3.2.27]
HV5AMMetazoa (kingdom)TNF receptor-associated factor 6 [EC:2.3.2.27],TNF receptor-associated factor 4
HICJJArthropoda (phylum)TNF receptor-associated factor 6 [EC:2.3.2.27]
86I1UHexapoda (subphylum)TNF receptor-associated factor 6 [EC:2.3.2.27]
AHB59Neoptera (infraclass)TNF receptor-associated factor 6 [EC:2.3.2.27]
ANNQ8Diptera (order)TNF receptor-associated factor 6 [EC:2.3.2.27]
H4NUNBilateria (clade)TNF receptor-associated factor 6 [EC:2.3.2.27]
7IX9HOpisthokonta (clade)TNF receptor-associated factor 6 [EC:2.3.2.27],TNF receptor-associated factor 4,TNF receptor-associated factor 5
EGX7XDrosophila (genus)TNF receptor-associated factor 6 [EC:2.3.2.27]
50EW2Sophophora (subgenus)TNF receptor-associated factor 6 [EC:2.3.2.27]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: