Domains within Mus musculus protein MOK_MOUSE (Q9WVS4)

MAPK/MAK/MRK overlapping kinase

Alternative representations: 1 /

Protein length420 aa
Source databaseUniProt
Identifiers MOK_MOUSE, Q9WVS4, ENSMUSP00000068904.8, ENSMUSP00000068904, Q8CFU4
Source gene ENSMUSG00000056458
Alternative splicing Q5M8P5_MOUSE, MOK_MOUSE, H3BLH6_MOUSE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

MOK_MOUSE is shown as Mok in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Mok

Protein MOK_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04113Meiosis - yeast

KEGG orthologous groups

KONameDescription
K08829MAKmale germ cell-associated kinase [EC:2.7.11.22]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000068904 in eggNOG.

OGTaxonomic classDescription
LKOG0661All organisms (root)male germ cell-associated kinase [EC:2.7.11.22],renal tumor antigen [EC:2.7.11.22],intestinal cell (MAK-like) kinase [EC:2.7.11.22]
KOG0661Eukaryota (superkingdom)male germ cell-associated kinase [EC:2.7.11.22],renal tumor antigen [EC:2.7.11.22],intestinal cell (MAK-like) kinase [EC:2.7.11.22]
HTXC5Metazoa (kingdom)intestinal cell (MAK-like) kinase [EC:2.7.11.22],male germ cell-associated kinase [EC:2.7.11.22],renal tumor antigen [EC:2.7.11.22]
94GTXChordata (phylum)renal tumor antigen [EC:2.7.11.22]
5QNDASarcopterygii (superclass)renal tumor antigen [EC:2.7.11.22]
8Z16NMammalia (class)renal tumor antigen [EC:2.7.11.22]
4RFU8Euarchontoglires (superorder)renal tumor antigen [EC:2.7.11.22]
AHZ7KRodentia (order)renal tumor antigen [EC:2.7.11.22]
8D82GMyomorpha (suborder)renal tumor antigen [EC:2.7.11.22]
7INNCOpisthokonta (clade)male germ cell-associated kinase [EC:2.7.11.22],intestinal cell (MAK-like) kinase [EC:2.7.11.22],renal tumor antigen [EC:2.7.11.22]
9GBQJVertebrata (clade)renal tumor antigen [EC:2.7.11.22]
H6VMUBilateria (clade)intestinal cell (MAK-like) kinase [EC:2.7.11.22],male germ cell-associated kinase [EC:2.7.11.22],renal tumor antigen [EC:2.7.11.22]
CQAHBMuridae (family)renal tumor antigen [EC:2.7.11.22]
ADWNYMurinae (subfamily)renal tumor antigen [EC:2.7.11.22]
5PEX9Mus (genus)renal tumor antigen [EC:2.7.11.22]
HEADJMus (subgenus)renal tumor antigen [EC:2.7.11.22]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: