Domains within Homo sapiens protein ANKR6_HUMAN (Q9Y2G4)

Ankyrin repeat domain-containing protein 6

Alternative representations: 1 /

Protein length727 aa
Source databaseUniProt
Identifiers ANKR6_HUMAN, Q9Y2G4, ENSP00000345767.4, ENSP00000345767, ENSP00000430985.1, ENSP00000430985, B3KUC3, Q5JUJ4, Q5JUJ5, Q8IUQ8, Q9NU24, Q9UFQ9, E5RIS1_HUMAN, E5RIS1, E5RJR9_HUMAN, E5RJR9, E5RJ45_HUMAN, E5RJ45, E5RIJ4_HUMAN, E5RIJ4
Source gene ENSG00000135299
Alternative splicing Q9Y2G4-1, ANKR6_HUMAN, Q9Y2G4-3, ENSP00000431061.1, ENSP00000429431.1, ENSP00000428377.1, E5RIN9_HUMAN, E5RH98_HUMAN, ENSP00000428309.1, E5RJ05_HUMAN, Q9Y2G4-4, H0YBG4_HUMAN, H0YBH4_HUMAN, H0YBW6_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

ANKR6_HUMAN is shown as ANKRD6 in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for ANKRD6

Protein ANKR6_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05169Epstein-Barr virus infection
map04722Neurotrophin signaling pathway
map05166Human T-cell leukemia virus 1 infection

KEGG orthologous groups

KONameDescription
K10999CESAcellulose synthase A [EC:2.4.1.12]
K06867K06867uncharacterized protein
K06499CEACAM, CD66carcinoembryonic antigen-related cell adhesion molecule

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000345767 in eggNOG.

OGTaxonomic classDescription
LCOG0666All organisms (root)uncharacterized protein,Mce-associated membrane protein,cellulose synthase A [EC:2.4.1.12]
KOG0504Eukaryota (superkingdom)cellulose synthase A [EC:2.4.1.12],beta-mannan synthase [EC:2.4.1.32],uncharacterized protein
HUPK9Metazoa (kingdom)carcinoembryonic antigen-related cell adhesion molecule,NF-kappa-B inhibitor alpha,nuclear factor NF-kappa-B p105 subunit
93GZ9Chordata (phylum)ankyrin repeat domain-containing protein 6
5QQAGSarcopterygii (superclass)ankyrin repeat domain-containing protein 6
8ZCUXMammalia (class)ankyrin repeat domain-containing protein 6
4RHKIEuarchontoglires (superorder)ankyrin repeat domain-containing protein 6
4ZXMIPrimates (order)ankyrin repeat domain-containing protein 6
987M5Haplorrhini (suborder)ankyrin repeat domain-containing protein 6
BUXW6Simiiformes (infraorder)ankyrin repeat domain-containing protein 6
9EZ20Catarrhini (parvorder)ankyrin repeat domain-containing protein 6
7MMYUOpisthokonta (clade)carcinoembryonic antigen-related cell adhesion molecule,ankyrin repeat domain-containing protein 50,NF-kappa-B inhibitor alpha
H58U6Bilateria (clade)carcinoembryonic antigen-related cell adhesion molecule,NF-kappa-B inhibitor alpha,ankyrin repeat domain-containing protein 6
9FBNXVertebrata (clade)ankyrin repeat domain-containing protein 6
FX9JYHominoidea (superfamily)ankyrin repeat domain-containing protein 6
5N70KHominidae (family)ankyrin repeat domain-containing protein 6
5Y7QBHomininae (subfamily)ankyrin repeat domain-containing protein 6

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: