Domains within Homo sapiens protein PCDA5_HUMAN (Q9Y5H7)

Protocadherin alpha-5

Alternative representations: 1 /

Protein length936 aa
Source databaseUniProt
Identifiers PCDA5_HUMAN, Q9Y5H7, ENSP00000436557.1, ENSP00000436557, O75284, Q8N4R3
Source gene ENSG00000204965
Alternative splicing Q9Y5H7-2, Q9Y5H7-3, PCDA5_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Coelomata

Predicted functional partners

PCDA5_HUMAN is shown as PCDHA5 in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for PCDHA5

Protein PCDA5_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04391Hippo signaling pathway - fly
map04514Cell adhesion molecules

KEGG orthologous groups

KONameDescription
K16499PCDHD2protocadherin delta 2
K16494PCDHBprotocadherin beta

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000436557 in eggNOG.

OGTaxonomic classDescription
LKOG3594All organisms (root)protocadherin delta 2,protocadherin delta 1,protocadherin beta
KOG3594Eukaryota (superkingdom)protocadherin delta 2,protocadherin delta 1,protocadherin beta
HV0V3Metazoa (kingdom)protocadherin delta 2,protocadherin beta,protocadherin delta 1
94N9WChordata (phylum)protocadherin beta,protocadherin delta 2,protocadherin gamma subfamily A
5QSQFSarcopterygii (superclass)protocadherin beta,protocadherin alpha,protocadherin gamma subfamily A
8YXFGMammalia (class)protocadherin alpha,protocadherin gamma subfamily A,protocadherin gamma subfamily B
4RBCMEuarchontoglires (superorder)protocadherin alpha,protocadherin gamma subfamily A,protocadherin gamma subfamily B
4ZUK9Primates (order)protocadherin alpha,protocadherin gamma subfamily A,protocadherin delta 2
98RUGHaplorrhini (suborder)protocadherin delta 2,protocadherin alpha
BVCX1Simiiformes (infraorder)protocadherin delta 2,protocadherin alpha
9EJVECatarrhini (parvorder)protocadherin delta 2,protocadherin alpha
7HVIPOpisthokonta (clade)protocadherin delta 2,protocadherin delta 1,protocadherin beta
H59A0Bilateria (clade)protocadherin delta 2,protocadherin beta,protocadherin delta 1
9FKQNVertebrata (clade)protocadherin beta,protocadherin delta 2,protocadherin gamma subfamily A
FXC4ZHominoidea (superfamily)protocadherin alpha
5MYWXHominidae (family)protocadherin alpha
5XSVJHomininae (subfamily)protocadherin alpha

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: