Domains within Rickettsia prowazekii str. Madrid E protein NTRXL_RICPR (Q9ZCY9)

Putative response regulator NtrX-like

Alternative representations: 1 /

Protein length475 aa
Source databaseUniProt
Identifiers D5AXF9_RICPP, D5AXF9, NTRXL_RICPR, Q9ZCY9

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Bacteria

Predicted functional partners

NTRXL_RICPR is shown as RP562 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for RP562

Protein NTRXL_RICPR is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map02020Two-component system

KEGG orthologous groups

KONameDescription
K07712glnG, ntrCtwo-component system, NtrC family, nitrogen regulation response regulator GlnG
K13599ntrXtwo-component system, NtrC family, nitrogen regulation response regulator NtrX

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 272947.gene:17555642 in eggNOG.

OGTaxonomic classDescription
LCOG2204All organisms (root)two-component system, NtrC family, nitrogen regulation response regulator GlnG,two-component system, NtrC family, response regulator AtoC,two-component system, NtrC family, nitrogen regulation response regulator NtrX
COG2204Bacteria (superkingdom)two-component system, NtrC family, nitrogen regulation response regulator GlnG,two-component system, NtrC family, response regulator AtoC,two-component system, NtrC family, nitrogen regulation response regulator NtrX
5Z77YProteobacteria (phylum)two-component system, NtrC family, nitrogen regulation response regulator GlnG,two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD,two-component system, NtrC family, nitrogen regulation response regulator NtrX
80X54Alphaproteobacteria (class)two-component system, NtrC family, nitrogen regulation response regulator NtrX,two-component system, NtrC family, nitrogen regulation response regulator GlnG,two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
9ZKAVRickettsiales (order)two-component system, NtrC family, nitrogen regulation response regulator NtrX
DSPD0Rickettsieae (tribe)two-component system, NtrC family, nitrogen regulation response regulator NtrX
6DKT2Rickettsia (genus)two-component system, NtrC family, nitrogen regulation response regulator NtrX

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: