NORMAL GENOMIC

• Sasahara K et al.
• Molecular cloning and expression analysis of a putative nuclear protein, SR-25.
• Biochem Biophys Res Commun. 2000; 269: 444-50
• Display abstract

• We cloned a full-length mouse cDNA and its human homologue encoding a novel protein designated as "SR-25." In Northern blot analysis, SR-25 mRNA was expressed in all organs tested, and relatively abundant in testis and thymus. Deduced amino acid sequences of mouse SR-25 and human SR-25 showed 77.7% identity. SR-25 has a serine-arginine repeat (SR repeat) and two types of amino acid clusters: a serine cluster and a highly basic cluster. Based on the presence of many nuclear localizing signals and a similarity to RNA splicing proteins, SR-25 is strongly suggested to be a nuclear protein and may contribute to RNA splicing.

• Kibardin AV, Mirkina II, Korneeva EA, Gnuchev NV, Georgiev GP, Kiselev SL
• Molecular cloning of a new mouse gene tagL containing a lysozyme-like domain.
• Dokl Biochem. 2000; 372: 103-5

• Mirkina II, Kiselev SL, Sashchenko LP, Sadchikova ER, Gnuchev NV
• [Cloning the human tag7 gene and study of its genomic organization]
• Dokl Akad Nauk. 1999; 367: 548-52

• Chadwick BP, Kidd T, Sgouros J, Ish-Horowicz D, Frischauf AM
• Cloning, mapping and expression of UBL3, a novel ubiquitin-like gene.
• Gene. 1999; 233: 189-95
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• A novel Drosophila melanogaster gene UBL3 was characterized and shown to be highly conserved in man and Caenorhabditis elegans (C. elegans). The human and mouse homologues were cloned and sequenced. UBL3 is a ubiquitin-like protein of unknown function with no conserved homologues in yeast. Mapping of the human and mouse UBL3 genes places them within a region of shared gene order between human and mouse chromosomes on human chromosome 13q12-13 and telomeric mouse chromosome 5 (MMU5).